Author: Sun-A Im1, , Young-Ran Lee1, Young-Hee Lee1, Myung-Koo Lee1, Young In Park2, Sungwon Lee3, Kyungjae Kim3 and Chong-Kil Lee1
in vitro cell culture systems, immunomodulatory activity in vivo, route of administration was intraperitoneal or intramuscular, in vivo immunomodulatory, evidence for the immunomodulatory activity of orally administered Aloe vera gel, immunomodulatory polysaccharides, such as acetylated mannan, glucomannan, galactogalacturan, Acemannan, a mixture of various length polymer chains of ?-(1,4)-linked acetylated galactomannan isolated from Aloe vera, may be the best-characterized immunomodulatory polysaccharides, acemannan completely cured or significantly reduced the tumor burden, Acemannan is also effective in the treatment of spontaneously developed canine and feline fibrosarcoma, immunoaugmenting activities of acemannan are mediated through the activation of macrophages, Acemannan activates macrophages to produce inflammatory cytokines such as IL-6 and TNF-a, increase NO production by macrophages, upregulate the phagocytic and candidicidal activities of macrophages, Acemannan also augments hematopoiesis, induces maturation of immature dendritic cells, healthcare products, immunomodulatory activity of Aloe components in in vitro cell culture systems, polysaccharides isolated from cellulose-treated, molecular size-activity relationship studies, optimal molecular size for maximum immunomodulatory activity, between 5 kDa and 400 kDa; polysaccharides smaller than 5 kDa or larger than 400 kDa exhibited only marginal immunomodulatory activity, HPLC analysis, Aloe vera gel exert immunomodulatory activity in vivo as well as in vitro, acemannan, the major polysaccharide present in Aloe vera gel, mediates its activity mainly through activation of macrophages
