Author: Ranade A, Ranpise NS, Ramesh C.
treatment for Helicobacter pylori?induced peptic ulcer includes a 14?day triple therapy of two antibiotics and a proton pump inhibitor. However, the current therapy has side?effects like stomach upset, non?compliance, incomplete absorption of drug and antibiotic resistance, best possible alternative is to deliver herbal constituents, present investigation is designed to deliver and retain two herbal constituents in the stomach for better action against gastric ulcers. The objective was to develop a bilayer floating tablet of monoammonium glycerrhizin and Aloe vera gel powder through rational combination of excipients to give the lowest possible lag time with maximum drug release in 7 h. Formulation OF2 containing hydroxy propyl methyl cellulose E5, rospovidone and effervescent agents in the ratio 1:2 gave 98% drug release with desired floating properties. Pharmacodynamic studies in rats showed that the combination of monoammonium glycerrhizin and Aloe vera gave 99% ulcer inhibition in comparison with 51% ulcer inhibition in the group administered with monoammonium glycerrhizin alone. X?ray studies in rabbits proved the gastroretention of the tablet for more than 6 h, this suggests relevance of NDDS in delivery of herbal constituents in the treatment of gastric ulcer, Aloe vera gel showed inhibition of gastric acid secretions by direct interaction with the acid-producing cells or possible interaction with H2 receptors on the parietal cells, the antiulcer activity is due to its anti-inflammatory, cytoprotective, healing and mucus-stimulatory effects, the gastroprotective activity of Aloe vera at lower concentrations is due to the presence of lectins. Lectins are proteins/ glycoproteins capable of binding to carbohydrate moieties
