Author A Yagi
aloe high molecular fractions (ALOE VERA HIGH MOLECULAR POLYSACCHARIDES) were obtained in original and natural form containing less than 10 ppm of barbaloin. ALOE VERA HIGH MOLECULAR POLYSACCHARIDES mainly contained high molecular fractions, such as polysaccharide (acemannan) and glycoprotein (verectin) showing immunomodulatory and anti-inflammatory activities. On the basis of chemical and biochemical properties, ALOE VERA HIGH MOLECULAR POLYSACCHARIDES were examined for the therapy designed by the implementation of well-controlled clinical trials, and exhibited the efficacy as immunomodulators for viral infection-induced hepatic periportal fibrosis and type 2 diabetic patients, and as wound and ulcer-healing ointment to patients suffering from bedsore. Therefore, ALOE VERA HIGH MOLECULAR POLYSACCHARIDES were considered to be a novel low-cost and safe drug of natural origin, indicating a possible therapeutic efficacy in prevention of age-related diseases, Aloe vera high molecular weight fractions; Therapeutic efficacy; Hepatic periportal fibrosis; Type 2 diabetes; Bedsores, Aloe polysaccharides High Molecular containing less than 10 ppm of barbaloin, polysaccharide (molecular weight 1×106 D) and glycoprotein, verectin (molecular weight: 29×103 D), were prepared by patented hyper-dry system in combination of freeze-dry technique with micro wave and far infra-red radiation. Aloe polysaccharides High Molecular produced significant decrease in blood glucose level sustained for 6 weeks of the start of the study. Significant decrease in triglycerides was only observed 4 weeks after treatment and continued thereafter. No deteriorate effects on kidney and liver functions were apparent, treatment of diabetic patients with Aloe polysaccharides High Molecular may relief vascular complications probably via activation of immune system, Oral supplementation with Aloe polysaccharides High Molecular could be helpful in alleviating the fibrosis and inflammation of hepatic fibrosis patients, efficacy of the preclinical trials for bedsores by the external use of Aloe polysaccharides High Molecular ointment, adjuvant properties of a poly dispersed ?-(1-4) linked acetylated mannan (ACE-M) were evaluated by Chinnah, et al[4] showing that ACE-M has the effect on flock immunity to Newcastle disease virus and infectious bursal disease virus. Acemannan also stimulated the adjuvant activity due to its capacity to promote differentiation of immature dendritic cells[5]. Intranasal immunization using HBsAg-acemannan formulations demonstrated the enhancement of the immune responses to nasally administrated hepatitis B surface antigen, generating IgG antibody-titers in high level in mice serum[6]. Acemannan was able effectively and durably to increase the activity of macrophages from the systemic immune compartment in chicken, especially nitrogen oxide (NO) production, Also human clinical data demonstrating increased bioavailability of vitamins C and E when taken in combination with aloe vera gel powders were presented, Aloe vera gel products improved the absorptions of vitamins C and E as an adjunct and arginine as a precursor of NO for people who take vitamins and amino acids supplements, he Japanese have higher rate of life expectancy and that Japan is rapidly becoming a super aging society. Almost 5 per cent of the aged, who develop diseases such as cerebro-vascular related disorders, mental problems, fractures, cancer and infections, also end up suffering from bedsores. It has been found that patients often opt for treatment, when the bedsores become very severe and adding more complications in their treatment. It may be presumed that prevention and early detection are vital for the treatment of bed sores. In our present study, we have tested herbal formulations having Aloe vera gel powder for its efficacy and activity on bedsores.
