Author: Jitendra Sainy1, Umesh Atneriya, Jagjiwan lal kori, Rahul Maheshwari
Desoximetasone, Plaque psoriasis; Emulgel; Skin penetration; Skin diseases; Kinetic, Plaque psoriasis, is highly prevalent form of psoriasis and basically an autoimmune disease which is challenging to treat. Being the skin disorder plaque is visible mostly on the skin, which causes red and white plaque of dead skin cell on elbow, knees, scalp, and lower back of body, they are usually unquiet, painful, and can crack and bleed, Desoximetasone, (11?,16?)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione (DMS) is a synthetic fluorinated corticosteroid known to exert anti pruritic and anti-inflammatory activity and most frequent medication for the treatment of plaque psoriasis , Despite its use in topical skin formulations, DMSs low water solubility and short half -life are the major obstacles impeding its therapeutic efficacy, emulgel are novel approach for effectively delivery of drug, depend on combined approaches, when gels and emulsions both are together in same dosage form that formulation is called as emulgel, Emulgel formulation were prepared for several classes of drug such as anti inflammatory drugs, anti fungal agent, anti- viral drugs, anti bacterial drugs, local anesthetic and plaque psoriasis ,therefore, emulgel were currently used as a carrier for delivery of various drugs to the skin, the major components of emulgel are emulsifying agent, gelling agent and oil phase, their concentration significantly affects the bioavailability of drug release from the formulation, the merit of emulgel include easily entrapment of water insoluble drugs into gel base with the help of oil in water emulsion system , which enhance cargo loading capacity, stability, and release of drug at controlled manner, Emulgel contained favorable properties for treatment of plaque psoriasis such as bio-friendly, thixotropic, easily spreadable, greaseless, easily removable, water soluble, skin softness, transparent, non-staining, pleasant appearance and stable, the ability of aloe vera to enhance the penetration power of drug and produce excellent emulsion into an emulgel, Their property of staying in contact with skin was explored to develop a emulgel formulation using aloe vera which would retained long period of time onto the skin and releases drug, spreadability and consistency, DMS emulgel was prepared, which can be significantly reached rate and extent of DMS across the cell membrane in controlled manner with help of aloe vera for prolong period of time in the treatment of plaque psoriasis, key benefit of transdermal delivery is to first bypass metabolism , the significant advantage of topical formulation to minimize the off target effect such as pH variation, empty stomach time, presence of enzyme so that topical formulation was exclude the difficulty and discomfort of endovenous treatment therapy, the present research work was to prepare DMS loaded emulgel for effective permeation using aloe vera
