Author Anurapa C, Suseem S.R*
oral control delivery system of highly water soluble drug using aloe vera powder as a carrier for matrix tablet. Ascorbic acid is taken as a model drug for its high solubility. Different concentrations such as 30 %, 40 % and 50 % of matrix tablets of Aloe Vera powder are made by wet granulation technique using starch paste as a binder, The formulated granules were further subjected to Quality control test such as Angle of repose (º), Bulk Density, Carr’s Index and Hausner ratio. These matrix tablets are then subjected to in vitro drug release using USP dissolution apparatus. The amount of ascorbic acid released from the matrix is estimated by using UV spectrometer and this result is compared with marketed ascorbic acid tablets. Formulation containing 40 % matrix was found to be good as compared to other two formulations and shows better controlled release of drug, Ascorbic acid tablet, Aloe Vera powder, Water soluble drug, Controlled drug delivery, route of drug delivery is Oral ingestion due to ease of administration and least sterility constraints, pain free administration, tablets may be formulated to offer rapid drug release or controlled drug release, the latter reducing the number of daily doses required, Oral controlled release of drugs with constant release rate has always been a challenge to the pharmaceutical field. There is a high possibility of faster rate of drug release for water soluble drugs if not formulated properly and likely to produce the toxic concentrations, when administered orally, for oral control delivery system of highly water soluble drug using Aloe Vera powder as a carrier for matrix tablet, ascorbic acid is taken as a model drug for its high solubility, Aloe Vera powder was used as a matrix which is naturally occurring and is most frequently used as drug carrier in pharmaceutical studies. Different concentrations, 30 %, 40 %, 50 % of matrix tablets of Aloe Vera powder are made by wet granulation technique using starch paste as a binder. The amount of ascorbic acid released from the matrix is estimated by using UV spectrometer and this result is compared with marketed ascorbic acid tablets, Aloe Vera based matrix tablets were prepared by wet granulation method using starch paste as binder, Aloe Vera Powder has acceptable flow properties and was further used for tablet formulations, out of three formulations prepared 40 % matrix contained formulation was found to be good , shows controlled release of drug whereas marketed drug show high release rate at first hour and then release rate was decreasing slowly
