Author: Saeed Alqahtani, Loqman Mohamed, Amal Kaddoum
For orally administered drugs, their intestinal absorption and hepatic metabolism are key players for determining a drug’s systemic bioavailability and thus therapeutic effect. Drug absorption and metabolism are both complicated processes, with many physicochemical and physiological factors involved. Understanding the contribution of each of these processes is essential in regulating a drug’s level in the bloodstream and in maintaining its optimum therapeutic outcome and safety, intestine and liver as barriers to drug delivery and systemic bioavailability, characterize and predict drug intestinal absorption and hepatic
