Authors: N Ranade, Arati; S. Ranpise, Nisharani; Ramesh, C.
Approach of novel drug delivery system (NDDS) overcomes the limitations of conventional dosage forms, delivery of herbal drugs , need to amalgamate the concept of NDDS in delivery of herbal constituents, deliver and retain two herbal constituents in stomach for better action against Helicobacter pylori induced gastric ulcers. The objective was to develop a bilayer floating tablet of ellagic acid and Aloe vera gel powder through rational combination of excipients to give the lowest possible lag time with maximum drug release in the period of 4 h. Formulation F9 containing 100 mg of HPMC K15M, 27 mg of crospovidone, 80 mg of mannitol and effervescent agents in the ratio 1:2 gave 92% drug release and desired floating properties. In vivo studies showed that combination of ellagic acid and Aloe vera gave 75 % ulcer inhibition in comparison to 57% ulcer inhibition in the group which was administered with ellagic acid alone. This suggests the use of bilayer floating tablet in gastric ulcer treatment, floating; gastric ulcer; optimization
