Author: Karaca K, Sharma JM, Nordgren R. 1995.
chicken spleen cells and HD11 line cells produce nitric oxide (NO) in response to Acemannan, complex carbohydrate derived from the Aloe vera, nitric oxide synthase inhibitor NG-methyl-l-arginine, Neither cell type produced detectable amounts of NO in response to similar concentrations of yeast mannan, another complex carbohydrate, ACM-induced NO synthesis may be mediated through macrophage mannose receptors, and macrophage activation may be accouantable for some of the immunomodulatory effects of ACM in chickens.