Author: Mangesh A. Bhutkar, Somnath D Bhinge, Dheeraj S Randive, Omprasad Nayakal, Prajakta Patil
Topical gel drug administration, drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes, Skin is one of the largest route of drug delivery action and readily accessible organs on human body for topical administration and is main route of topical drug delivery system, Skin penetration enhancers reversibly decrease the barrier resistance of the stratum corneum and allow drugs to penetrate more readily to the viable tissues and the systemic circulation, herbal penetration enhancers, penetration enhancer in topical pharmaceutical formulations, promotes permeation by reducing skin resistance to drug molecules or by promotion of drug partitioning from the dosage form, Spreadability, pH of gel formulations, Aloe vera (Aloe barbadensis Miller) gel has shown potential to enhance the permeation of certain drug molecules through skin membranes, Aloe vera as a natural penetration enhancer at a concentration of 3% may be used to enhance the penetration for drug molecules across the skin.
