Author: BARBARA JOANNA BA?AN1, MARCIN NIEMCEWICZ2, JANUSZ KOCIK2, LESZEK JUNG3, EWA SKOPI?SKA-RÓ?EWSKA4,2, PIOTR SKOPI?SKI5
Aloe vera (L.) Burm. f. (Aloe barbadensis Mill) Liliaceae, innovaloe powder 200x, AMB Wellness, manufacturer of aloe Raw materials from Mexico, inner part of parenchyma, which contains aloe gel, treatment of minor wounds, inflammatory skin disorders, thermal , radiation burns, alleviate chronic osteoarthritis pain, antimicrobial activity, aloe gel is a dietary supplement, immunomodulatory properties, orally administered aloe gel on some parameters of cellular and humoral immunity viz. mitogen-induced proliferation of splenic lymphocytes and their chemokinetic activity, and anti-sheep red blood cells (SRBC) antibody production, Daily treatment of mice for 14 and 21 days with 50 µl or 150 µl of aloe gel dose resulted in enhanced chemokinetic activity and stronger response of their splenic lymphocytes to mitogen PHA and enhancement of anti-SRBC antibody production, inhibitory activity, isolated cariogenic and periodontopathic bacteria, bacteriostatic effect on Listeria monocytogenes, Aloe gel and its extracts also exert antimicrobial activity against multidrug-resistant bacteria (MDR) , antimicrobial activity of Aloe vera against Staphylococcus aureus, Bacillus spp., Enterococcus spp., Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa and Vibrio spp, effect strong against E. coli and Vibrio spp , Salmonella typhimurium, growth inhibition activity of aloe gel against MDR Mycobacterium tuberculosis isolates, t Aloe vera juice incorporated into the growth media of Lactobacilli at a concentration of 5% was effective in promoting the growth of L. acidophilus, L. plantarum and L. casei, concentration higher than 25% showed an inhibitory effect, aloe gel in a lower concentration might be used in combination with probiotic Lactobacillus strains as a therapy for gastrointestinal disorders, t aloe gel suppressed bacterial-induced pro-inflammatory [tumor necrosis factor ? (TNF-?) and interleukin 1? (IL-1?)] cytokines production in human immune cells, protective effect of Aloe vera on polymicrobial sepsis, Aloe vera reversed the lethality and ameliorated the multiple organ dysfunction syndrome both by enhancing bacterial clearance and by attenuation of pro-inflammatory cytokines production, anti-inflammatory effect of Aloe vera was connected with down-regulation of MMP-9 activity, Aloe vera extracts may be used in eye drops to treat inflammations and other cornea ailments, aloe gel and its compounds on immunity are scanty, and mostly connected with its stimulatory effect on macrophages activity, possess immunomodulating action on primary humoral immune response
