Authors Divya Bansal/ Bhargava , Manoj Choudhary, Nazneen Dubey, Aditya Ganeshpurkar, Vikas Pandey, Tushar Salukhe
Natural gums and mucilage which hydrates and swells on contact with aqueous media are used as additives in the formulation of hydrophilic drug delivery system, develop a new monolithic matrix system for complete delivery, zero-order manner over an extended time period using processed Aloe vera gel mucilage (PAG) as a release modifier, dry blending of selected ratios of polymer and ingredients using direct compression technique, Physicochemical properties of dried powdered mucilage of Aloe Vera Gel , formulations of pioglitazone HCl and Aloe Vera Gel mucilage, direct compression technique, uniformity of weight and drug content, swelling behavior, Aloe vera mucilage powder can be used as a matrix forming material for controlled release of Pioglitazone HCl matrix tablets, use of natural occurring biocompatible polymeric material for designing of dosage form for oral controlled release administration, Gums and mucilage contain hydrophilic molecule, which can combine with water to form viscous solution or gels, Natural gums and mucilage, which hydrates and swells on contact with aqueous media, additives in formulation of hydrophilic drug delivery system, compliance and flexibility in developing dosage forms, oral drug delivery systems, development of such a system was to make use of Aloe Vera Gel gel as a release retardant material to control the rate of drug release by the tablets, compressibility index values up to 15% result in excellent flow properties, evaluation tests, such as thickness, hardness, friability, and uniformity of drug content, rate of drug release from the tablet formulations aloe vera mucilage powder 200X was highest, Tablets with high concentration of Aloe Vera Gel mucilage exhibited slow release of pioglitazone HCl as compared to commercially available SR tablet, Aloe vera mucilage act as a release retardant
