Author Tarkase K. N. and Danve V., Padmashree Dr. Vitthalrao Vikhe
achieve successful delivery of drug locally as well as systematically, rectal route, research, formulate and evaluate herbal extract Aloe Vera suppositories, Suppositories are inserted directly into the rectum to distribute their herbal powder to internal areas. Aloe Vera contains aloin, which is an anthraquinones glycoside. Aloin has been used as a laxative for constipation, laxative action, Suppositories of polyethylene glycol-l (PEG) 4000 and surfactant showed better permeation of drug and laxative action, Suppositories are designed for insertion into body cavities where they melt, soften or dissolve and exert local or systemic effects, the suppositories serve as an alternate where oral administration of drug is not suitable as in infants or patients suffering from nausea, vomiting and gastrointestinal disturbances, they provide the advantage that biotransformation of drugs in liver, pH conditions and gastrointestinal enzymes are avoided, suppository base play vital role in the release of medicament they hold the drug. The important property of suppository base is that it should remain solid at room temperature but soften, melt or dissolve readily at body temperature so that the drug is released after its administration, Herbal Suppositories of Aloe Vera can be used in patients suffering from nausea, gastric ulcers, comatose patients, geriatrics where administration is difficult or not possible through oral route. Studies have showed that the release characteristic of suppositories depends on the physicochemical properties of the drug, its carrier (suppository base) and surfactants, the particle size of drug and chemical composition increase or decrease the rate of release
