Author: Junginger, H.E.; Verhoef, J.C.
penetration enhancers poly(acrylates) chitosan N-trimethyl chitosan mucosal membrane barriers transport mechanisms tight junctions hydrophilic drugs peptides proteins, low molecular weight transmucosal penetration enhancers for improved absorption of hydrophilic drugs, novel types of macromolecular penetration enhancers, such as anionic polyacrylates and cationic chitosan and chitosan derivatives, have been developed, enhance the paracellular permeability of mucosal epithelia (intestinal, nasal) by transiently opening the tight junctions, transmucosal delivery of hydrophilic drugs
