Author Z Zheng, X Pan, L Luo, Q Zhang, X Huang, Y Liu
Polysaccharides have been widely used as biomaterials and drugs after oral administration due to their suitable physicochemical properties, good bioactivities and low toxicities, pharmacokinetics and absorption mechanism, oral administration, polysaccharide detection technologies such as immunoassays, fluorescent and isotopic labelling, the oral pharmacokinetics of polysaccharides, paracellular pathway, transcellular pathways and M cell-mediated transport were analyzed as mechanisms for oral absorption. The potential factors affecting the oral absorption of polysaccharides, including their charge, molecular weight, spatial structure and dose, as well as the species and physiological state of organisms, were analyzed. Based on the absorption mechanism and influencing factors, we look forward to further investigating possible strategies for improving the oral absorption of polysaccharides, cell Microfold, cell Mw Molecular weight, TJ Tight junction 99mTc99m-technetium HA Hyaluronan SIPS quid ink polysaccharide FTSC Fluorescein-5-thiosemicarbazide TEER Transepithelial electrical resistance GFP Grifola frondosa polysaccharide APTSAminopyrene-1,3,6-trisulfonate LBP Lycium barbarum polysaccharide SCLPS milax china L. polysaccharide PM Polymannuronic acid PG Polyguluronic acid GALT Gut-associated lymphoid tissue DTAF5-(4,6-Dichlorotriazinyl) aminofluorescein TMCN-trimethyl chitosan Cmax Maximum plasma concentrationFDFITC-dextranLMWHLow molecular weight heparinDOCADeoxycholic acid AUC Area under the curve BAT Bile acid transport GLP Ganoderma lucidum polysaccharide PL Phospholipids LMWCS Low molecular weight chondroitin sulfate?-LNA?-Linolenic acid GSH Glutathione OJP Ophiopogon japonicus polysaccharide CCP Coptis chinensis Franch polysaccharide SNAD Sodium N-[10-(2-hydroxybenzoyl) amino] decanoate SNAC Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate APSAstragalus polysaccharidesaPTTActivated partial thromboplastin time
