Author: S. Gupta
protection against radiation, anti-oxidant, anti-inflammation, aloe polysaccharides, skin moisturizers, aloe is an excellent ingredient for pros for face and hand creams, cleansers, soaps, suntan lotions, sunscreens, skin whiteners, shampoos and hair tonics, shaving preparations, bath aids, makeup and fragrance preparations to baby lotions and wipes, aloe vera component compounds, including anthraquinones, saccharides, polysaccharides, lignin, and numerous low molecular weight compounds such as vitamins and salicylic acid, bioactive maloyl glucans, synergistic action of the various components of Aloe vera gel contribute to the occurrence of a wide array of biological functions, UV-opacity potential of the gel, synergetic action between the polysaccharide moiety and other components in Aloe Gel, Skin regeneration involves inflammation, cell proliferation and contraction of collagen lattice formation, Wound healing is the process of repair and regeneration of dermis and epidermis that follows injury to the skin and other tissues of the body, macrophage activation, stimulate wound healing by increasing keratinocyte proliferation and migration , Collagen is the major protein of the extracellular matrix, and is the component which ultimately contributes to wound strength, aloe vera gel AG can inhibit matrix metalloproteinase in a dose-dependent manner, The effects of acemannan on gingival fibroblasts proliferation, keratinocyte growth factor-1 (KGF-1), vascular endothelial growth factor, type I collagen production and oral wound healing was investigated in murine model, Acemannan at 2-16 mg/ml significantly stimulated keratinocyte growth factor 1, vascular endothelial growth factor, and type 1 collagen expressions, components of AG contain mannose-6-phosphate that fits into growth receptors present on fibroblast cells and stimulates them, concept that fibroblast cells which are key cells in forming the structure of connective tissue possess special receptors, which are sensitive to mannose-6-phosphate and hence to mannose-containing polysaccharides, mannose-containing glycoproteins, and breakdown products derived from these large mannose rich molecules, natural antioxidants to prevent the deleterious effects of free radicals, Any imbalance in the cellular metabolism can lead reactive oxygen species (ROS) to do oxidative damage to cellular membranes or intracellular molecules
