Author Panahi Y, Sharif MR, Sharif A, Beiraghdar F, Zahiri Z, Amirchoopani G, et al.
Diaper dermatitis (DD) is a common inflammatory disorder among children and infants, It refers to any acute inflammatory skin eruption that occurs in area covered by diaper and caused by either direct effect of wearing diapers or as a result of increased skin pH, zinc deficiency, prolonged exposure to moisture, and irritants like urine and feces. The combination of these factors leads to overhydration of the stratum corneum as well as chemical and mechanical abrasion, which compromises barrier function and makes the stratum corneum more susceptible to frictional trauma and the penetration of irritants and microbes. In addition, the presence of microorganisms especially Candida plays a secondary role in the development of DD [2, 6]. DD is uncommon during the first few months of life as fecal enzymes are present in low levels during this period. It usually peaks between 6 and 12 months of age and may continue till diapers are not further used in children negative side effects such as irritation, erythema, and papules, it is essential to identify effective strategies in order to decrease the prevalence of DD in children or infants, particularly if a patient does not respond to standard therapy, use of medicinal plants as antibacterial and anti-inflammatory drugs as Aloe vera and C. officinalis are two medicinal plants with diverse biological activities including anti-inflammatory and antimicrobial effects, compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of Diaper dermatitis in children, topical Aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants,
