Author Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R.
Wound healing, a complex interaction among cells, extracellular matrix, blood vessels, proteases, cytokines, and chemokines, is still a controversial topic in surgical medicine, several complications such as delayed wound healing, superficial wound infection and post-operative/post-traumatic neuropathic chronic cutaneous pain have been reported by patients who had closed incisional wounds after the surgery, Aloe vera, an herbal plant of the lily family, has been used to treat various diseases for centuries , topical application of Aloe vera as a natural remedy, has contributed to the rapid tissue repairing process of burns, wounds, frostbite, skin infection and dermatitis, active molecules that act on fibroblasts, macrophages and epidermal cells activity, stimulate formation of epidermal tissue, increase collagen synthesis and remodeling and enhance tensile stress, thyroid hormone has been recommended as a potential wound healing agent, efficient in stimulating keratinocyte proliferation, epidermal proliferation, dermal thickening and hair growth in vitro, thyroid hormone enhances local response to growth factors and gene expression of keratins, Silver sulfadiazine (SSD) is a common anti-infective agent used to control bacterial proliferation and manage wound infection. Although indicated for deep partial-thickness and full-thickness injuries and suggested as effective in reducing inflammatory and granulation phases of healing in sutured incisions, SSD has been reported to have cytotoxic effects on fibroblasts and keratinocytes in vitro and retard wound healing in vivo , despite this, SSD is the most extensively used topical agent for the treatment of wounds effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream on sutured incisions in Wistar rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P?0.05), results indicated that Aloe vera was significantly more effective in wound healing as attested by tensile stress parameters in sutured incisions
