Author: Chander Pal Singh Verma, Santosh Verma, Mahendra Singh Ashawat, Vinay Pandit
the ideal characteristic of bioenhancers includes inertness, nontoxic, cost effective and decrease the dose of active constituents. There are lots of natural bioenhancers available such as piperine quercetin, niaziridin, genistein, glycyrrhizin, curcumin, the review focus on plant based bioenhancers and their active principle that produces those effects, there is a need of extensive study on natural bioenhancers which can be utilized in formulation development, Drugs that are administered orally go through a dissolution process and then permeation across the gastric membrane before they can appear in the blood stream, the amount of drug that goes into the bloodstream from its site of administration is defined as its bioavailability, solubility is defined as the property of a substance to dissolve itself into a solid, liquid or a gaseous solvent to form a homogeneous solution of it. Solubility of a drug in gastric media is an essential requirement for an orally administered drug to be absorbed adequately, the majority of factors that affect the bioavailability of a drug other than solubility and permeability include the dissolution rate of the drug, first-pass effect, pre-systemic metabolism of the drug in any other organ and susceptibility to efflux mechanisms, Solubility in the gastric media is a major problem associated with orally administered drugs that leads to erratic bioavailability, use of bio enhancers is a promising approach to overcome the issues related to bioavailability. A bioenhancer enhances the bioavailability of a drug molecule without causing any pharmacological activity of its own, bio enhancers of herbal origin have gained interest recently and many herbal compounds , A herbal bioenhancer is an agent of herbal origin that has the capability to enhance that bioavailability of a drug with which it is combined, without causing any pharmacological activity of its own, Adding a bioenhancer to a drug helps to reduce drug dosage, drug cost, incidences of drug resistance and risks of adverse drug reaction. Most importantly, a bioenhancer improves the efficacy of a drug by enhancing its bioavailability. In addition, adding a bioenhancer also reduces raw material requirement during pharmaceutical manufacturing
