Author: Andra Tudose, C. Celia, Margherita Vono, R. Molinaro, D. Paolino, S. Venuta, Viale S. Venuta, C. Davila

aloe vera has a positive influence in different inflammatory skin disorders, regenerative properties of Aloe Vera juice are investigated on human keratinocyte cells, Aloe Vera juice could represent a natural therapeutic strategy through the topical route, therapeutic and cosmetic approaches, plant-based treatments, anti-inflammatory activity and skin regenerating effects, photoprotectants against harmful effects of UV radiation, regenerative properties of Aloe Vera juice on human keratinocyte cell culture, namely NCTC2544 human cell line, cellular growth was directly proportional to the concentration of plant juice used

Author: . Sahu, P. K., D. D. Giri, R. Singh, P. Pandey, S. Gupta, A. K. Shrivastava, A. Kumar and K. D. Pandey 2013.

Aloe vera; Antimicrobial; Therapeutic; Medicinal Uses;, aloe gel Inner Layers of Leaf, Active Ingredients, Acemannan is considered the main functional compo-nent of Aloe vera, is composed of a long chain of acety-lated mannose, Macrophage-activating potential acermannan may stimulate the release of fibrogenic cy-tokines, Muco-polysaccharides help in binding moisture into the skin. The amino acids also soften hardened skin cells and zinc acts as an astringent to tighten pores, Effects on the Immune System, Cosmetic & Skin Protection Application

Author Kostalova D, Bezakova L, Oblozinsky M, Kardosova A (2004)

Molecular weight of proteins calculated from the sets of molecular weight reference standards, ranged from 70 kDa for the largest to 14 kDa for the smallest ones, aloe vera , acemannan , polysaccharides , carbohydrate copound is acetylated (1 –> 4)-beta-D-mannan substituated with D-galactose and D-glucose.

Author: S Laneri, RM Di Lorenzo, […], A Bernardi, A Sacchi, and I Din

antiaging efficacy of dermocosmetic formulations containing A. barbadensis, derma firmness, elasticity, nutricosmetic, developing innovative cosmetic products, scaly and flaky appearance or the xerosis of the skin, occur in the absence or deficiency of water, Moisturization is a crucial point to maintain the skin soft, flexible, smooth, wrinkle- free, and therefore preserve a youthful and beautiful appearance, Hydration is critical for the typical operation of the skin and its cells, Water levels mainly depend on the nature of the stratum corneum (SC), the outermost epidermal layer of the skin, the aging, and the destructive agents like the heat and the wind, epidermis has 2 different levels of water, separated by the interface between the stratum granulosum (SG) and the stratum corneum (SC), Water present in the deeper epidermal layers goes upward to hydrate cells in the SC, and in part, it is lost by evaporation, formulation of innovative products for beauty care with proven effectiveness , aloe cosmetics formulation development

Author: M. H??, K. Dziedzic, J. L. Thanh-Blicharz, D. Kmiecik, D. Górecka

Aloe contains numerous bioactive compounds, antioxidant in aloe, reactions of lipid oxygenation, raw materials rich in bioactive compounds showing health-promoting advantages, chemical composition, content of polyphenolic, aloe vera concentrate, gel, juice or powder, aloe leaf flesh juices, International Aloe Science Council (IASC) certification, anti-radical activity

Authors:Sandeep Kumar

plant undergoes Crassulacean acid metabolism (CAM) metabolic pathway for conserving water within the parenchymatous tissues to withstand drought like conditions, Aloe helps with the breakdown of food sugars and fats, aiding digestion and enhancing nutrient absorption, Bradykinase which helps to reduce excessive inflammation, Antioxidant, neutralizes free radicals, aminoacids Provides the basic building blocks of proteins in the production of muscle, tissue , Lignin, an inert substance enhances penetrative effect of the other ingredients into the skin. Auxins and gibberellins help in wound healing and have anti-inflammatory action. Salicylic acid that possesses anti-inflammatory and antibacterial properties Saponins that are the soapy substances have cleansing and antiseptic properties, biological activities of A. vera are due to the synergistic action of a variety of compounds, rather than from a single defined component

Author: Miyuki Tanaka, Eriko Misawa, Koji Yamauchi, Fumiaki Abe, Chiaki Ishizaki

Aloe sterols, Aloe sterols are a type of plant sterols that have the capability to regulate the metabolism of glucose and lipids, Aloe sterols reached the peripheral tissues through the bloodstream, aloe sterols, the production of collagen and hyaluronic acid increased by two-fold and 1.5-fold, gene expression levels human dermal ?broblasts, immunological responsiveness, acemannan stimulated the synthesis of keratinocyte growth factor-1 and vascular endothelial growth factor by gingival ?broblasts in vitro, Fibroblasts represent the main cellular population of the dermis, Aloe sterols (lophenol [Lop], 24-methyl-lophenol, 24-ethyl-lophenol, cycloartanol [Cyc], and 24-methylene-cycloartanol) are plant sterols derived from A. vera gel and possess unique ef?cacy, Aloe sterols fall into two groups of compounds, the Lop group and the Cyc group, Collagen forms the three-dimensional structure, and elastin maintains the elasticity of the skin. HA is responsible for moisture retention in the skin. Fibroblasts play an important role in generating collagen, HA, and elastin in the dermis

Author: Sima Ghanipour Badelbuu, Yousef Javadzadeh, Mahnaz Jabraeili, Shiva Heidari, Mohammad Arshadi Bostanabad

Diaper dermatitis, inflammation of the skin under the diapers of children, degree of urinary incontinence, Aloe vera ointment, chamomile ointment, diaper dermatitis, several factors such as wear, moisture, urine and stool and PH changes, Irritation of the area and burning, dryness, scratching and skin irritation are key features. Infiltration of agents and germs can cause infectious, bacterial, and fungal infections, diagnosis of pemphigus, burn and syphilis and seborrheic dermatitis

Author: Akinnyele, B.O. and Odiyi, A.C. 2007.

Enzymes that are beneficial to human metabolism such as amylase, bradykinase, catalase, cellulose, lipase, oxidase, phosphokinase, proteolytiase and carboxypeptidase can also be obtained from the plant, vitamin B (including B1, B2, B3, B6, B12), vitamin C, vitamin E, folic acid and minerals. The minerals such as magnesium, calcium, potassium, phosphorus, sodium, manganese, zinc, copper, nitrogen, iron and chromium found in the gel all contribute to the healing property of A. vera, contains glutamic acids, aspartic acid, aloetic acid, formic acid, palmitic acid, estearic acid and ascorbic acid all of which are essential components of food, vegetative morphology,

Author Marzanna H??, Krzysztof Dziedzic, Danuta Górecka, Anna J?drusek-Goli?ska & El?bieta Gujska

Aloe vera have an anti-inflammatory effect and support lipid and carbohydrate metabolism, helping to maintain normal sugar and cholesterol levels in blood and normal body weight, it accelerates the regeneration of the damaged skin, Aloe contains antioxidants, bioactive components and the health-promoting effects of A. vera, Antioxidants are substances that prevent oxidation of other compounds, Food phenolics render antioxidant activity mainly due to their role as reducing agents, hydrogen donors, and singlet oxygen quenchers, ability to scavenge free radicals, including hydroxyl, peroxyl, and superoxide radicals and can form complexes with catalytic metal ions rendering them inactive, flavonoids can inhibit lipoxygenase and cyclooxygenase enzymes, responsible for development of oxidative rancidity in foods, Aloe contains a large amount of bioactive compounds, such as flavonoids, terpenoids, lectins , fatty acids, anthraquinones , mono- and polysaccharides (pectins, hemicelluloses, glucomannan), tannins, sterols (campesterol, ?-sitosterol), enzymes, salicylic acid, minerals (calcium, chromium, copper, iron, magnesium, manganese, potassium, phosphorus, sodium and zinc) and vitamins (A, C, E, ?-carotene, B1, B2, B3, B6, choline, B12, folic acid), Glycoproteins are natural polymers that combine proteins, carbohydrates and 16 amino acids, Lectins (aloctin A and B) are a group of glycoproteins, which is characteristic of aloe, activation of cell blastic transformation, where the cell transformation from phase G0 (resting phase) to phase G1 (interphase) or synthesis is induced. Mitotic divisions are stimulated in consecutive processes

Author: Hanna Svitina, Roan Swanepoel, Jacques Rossouw, Happiness Netshimbupfe, Chrisna Gouws and Josias Hamman*

physiological roles, barrier to protect the underlying tissues against the elements and pathogens, Skin disorders, biochemical functions such as preventing excessive water loss, Aloe vera is the most commonly used Aloe species for medicinal purposes, skin related applications and disorders, treatment of skin related disorders, Cosmetic and cosmeceutical products, maintain and protect skin through proper hydration, which can improve skin function and appearance, External factors and topical irritants can disturb or remove the stratum corneum water content and surface lipids of the skin, eventually leading to dry skin and atopic dermatitis, Skin hydration aims to increase and maintain surface moisture and homeostasis, while delaying aging and treating cosmetic problems, aloe is a cosmetic agent to improve skin appearance and beauty, cosmetic products at low concentrations as skin-conditioning agents, Aloe vera leaf extract and leaf polysaccharides are also known emollients and humectants, astringent to contract the skin and remove dead skin cells, since zinc can tighten pores, Aloe materials can protect the skin against free radical damage through its antioxidant properties, cleansing and antiseptic actions of soapy saponins, the antiinflammatory effects of phytohormones and sterols such as cholesterol, and ß-sitosterol and other bioactivities of the complex polysaccharides, reduces drying and irritation of the skin. The polysaccharides are also useful in a soap-type shave cream, acting as a lubricant due to its mucilaginous nature, penetrate the dermal layers deeply, allowing moisturizers and water to restore fluid loss and replenishing the fatty layer, Acemannan mucopolysaccharides assist in moisture retention of the skin, as a humectant and can be added to nonionic, cationic or anionic moisturizing products, although the quantity is limited in anionic emulsions , emulsifying system due to its pH of 4.0 – 5.0, Skin aging is a general and inevitable human dermatologic condition, characterized by loss of extracellular matrix in the epidermal and dermal layers, prevent and repair damage to reduce wrinkles and create younger looking skin, A. vera is used as an anti-aging treatment, since it is known to soften skin and encourage regeneration by stimulating cell proliferation through the amino acids such as arginine, asparagine, glutamic acid, aspartic acid, serine and enzymes it contains, free radical damage is a key mechanism in the aging of skin, since these free radicals can damage structural cell membranes, lipids, proteins and DNA, antioxidant and anti-aging components in Aloe juice possibly include flavonoids, oligo-elements such as manganese and selenium, and superoxide dismutase and glutathione peroxidase enzymes, although aloin, anthones and chromones may also be involved, antioxidant activities of Aloe polysaccharides, however, can be influenced by the degree of acetylation, glycosidic branching, type of sugar and molecular weight

Author: Patrícia Maria Berardo Gonçalves Maia Campos, Maisa Oliveira de Melo & Flavio Bueno de Camargo Junior

The knowledge of the skin biology allows the identification of which active ingredients are important for the maintenance of its integrality and barrier function, essential to skin health, development of cosmetic formulations, improve the efficacy of the formulations, maintaining the skin in good conditions, improve formulation stability and sensorial properties, polysaccharide-based formulations promoted the transepidermal water loss reduction, protecting the skin barrier function

Author: Laneri, S.; Di Lorenzo, R.M.; Bernardi, A.; Sacchi, A.; Dini, I.

aloe formulation for Glamour Cosmetics (Hydrophilic),Sun Care and After Sun Products , Hand and Body Lotions/Gels, Skin Cleansers/Moisturizers ,Bath and Body Products, Shampoos and Conditioners, Shaving/Depilatory Preparations, Styling/Sculpting Gels, Bath Powders, Toothpastes/Oral Rinses, Hand Lotions, Body Lotions, Facial Cleansers and Moisturizers, Shampoos, Conditioners, Styling Gels, Shaving/Depilatory Creams, makeup, lipbalm, lipstick, pet shampoo, pet conditioner,

Authors: Marta Sánchez , Elena González-Burgos , Irene Iglesias , M. Pilar Gómez-Serranillos

skin hydrating and anti-erythema activity, irritated skin areas, volar forearm skin of female, dehydrating effect on the skin after multiple applications, reduce erythema on the skin, Aloe barbadensis Miller (Aloe vera), polisaccharidic fractions, polydispersed ?-1,4-linked mannan substituted with O-acetyl groups, acetylated mannan (Acemannan), skin as it appears to be a super emollient with very important moisturizing capabilities, phytoconstituents, retention of water and the hydration balance in the superficial skin layers ensures the skin’s elasticity and flexibility, A. vera extract showed a humectant mechanism when improving skin moisture as it significantly increased the water content of the stratum corneum (SC) although it did not alter the transepidermal water loss (TEWL)