Author Pugh N, Ross SA, ElSohly MA, Pasco DS
aloe vera (Aloe barbadensis) juice, immunostimulatory polysaccharide, Aloeride is between 4 and 7 million Da, glycosyl components include glucose (37.2%), galactose (23.9%), mannose (19.5%), and arabinose (10.3%), glycoprotein has been found to increase proliferation of normal human dermal cells, major composition of aloe gel consists of a mucilage of polysaccharide substances, polysaccharides are glucomannans, mannans, or pectins having a range of molecular weights, acemannan , consists of a polydispersed â-1,4-linked acetylated mannan interspersed with O-acetyl groups, aloe components may enhance wound healing is by activation of macrophages, production of cytokines by macrophages requires activation of these cells, and prolonged wound healing times in aged mammals may be symptomatic of impaired macrophage function, Pharmacological activities of acemannan include antiviral effects (7), activation of macrophages , stimulation of T cells (9), and induction of nitric oxide production, activation of transcription factor NF-kappa B controls the expression of multiple genes in activated monocytes/macrophages, Target genes regulated by NF-kappa B include proinflammatory cytokines, chemokines, inflammatory enzymes, adhesion molecules, receptors, and inhibitors of apoptosis
