Author: Sriram Rajashree and Chellan Rose* Department of Biotechnology, CSIR- Central Leather Research Institute, Adyar, Chennai – 600020, Tamil Nadu, India.
Exposure to Ultraviolet radiations accelerates skin aging, wrinkles, laxity, dyspigmentation, roughness and dryness, natural biomaterials, fibroblasts cells on incubation with Aloe Vera, increased proliferation rate and the absence of blue stain indicated that the process of senesce has been reversed, aloe gel helps in regeneration and rejuvenation of the skin, skin aging has become a major symptom, involving the process of photo induced oxidative reactions and exposure to pollutions, Repetitive exposure to UV radiation, leads to free radical formation which breaks down the lipids to form malondialdehyde, malondialdehyde. This MDA subsequently cross-links with collagen, leading to the loss of skin elasticity and decreased moisture holding capacity which are very much related to the most obvious symptom of skin wrinkling, photoaging, dermal damage with marked elastotic degenerative change, collagen loss, reduction in number and size of fibroblasts, an increase in proteoglycans and a moderate mononuclear inflammatory cell infiltrate, capacity to proliferate fibroblasts cells and increase collagen production and secretion
