Author: Miyuki Tanaka, Eriko Misawa, Koji Yamauchi, Fumiaki Abe, Chiaki Ishizaki
Aloe sterols, Aloe sterols are a type of plant sterols that have the capability to regulate the metabolism of glucose and lipids, Aloe sterols reached the peripheral tissues through the bloodstream, aloe sterols, the production of collagen and hyaluronic acid increased by two-fold and 1.5-fold, gene expression levels human dermal ?broblasts, immunological responsiveness, acemannan stimulated the synthesis of keratinocyte growth factor-1 and vascular endothelial growth factor by gingival ?broblasts in vitro, Fibroblasts represent the main cellular population of the dermis, Aloe sterols (lophenol [Lop], 24-methyl-lophenol, 24-ethyl-lophenol, cycloartanol [Cyc], and 24-methylene-cycloartanol) are plant sterols derived from A. vera gel and possess unique ef?cacy, Aloe sterols fall into two groups of compounds, the Lop group and the Cyc group, Collagen forms the three-dimensional structure, and elastin maintains the elasticity of the skin. HA is responsible for moisture retention in the skin. Fibroblasts play an important role in generating collagen, HA, and elastin in the dermis
