Author: Himansu Bhusan Samal, Itishree Jogamaya Das, Ch. Niranjan Patra, P. N. Murthy
develop and evaluate dental film containing Aloe Vera extracts for the treatment of Periodontitis, Aloe Vera shows wide spectrum of antibacterial activity against several periodontal pathogen and hence selected for site specific delivery for the treatment of Periodontitis. Aloe vera is formulated into dental films by solvent casting technique using polymers such as Ethyl cellulose, Carbopol 971P and HPMC K4M with PEG 4000 as plasticizer and prepared films (F1-F8) were evaluated for various properties such as weight variation, tensile strength, moisture loss, drug content, in-vitro drug release, In-Vitro dissolution studies showed an initial burst release to achieve immediate therapeutic level of drug in periodontal pocket followed by a progressive fall and extended release of the drug with more uniformity for prolonged period of time. Stability studies did not show any significant changes with respect to content and appearance. In-vitro experiments demonstrated that the prepared film F8 represent a suitable dosage form to release Aloe vera for 96 h and considered as the Optimized formulation, Periodontal disease is recognized as a major public health problem throughout the world and occurs in all groups, ethnicities, races, genders and socioeconomic levels, it is characterized by inflammation and degeneration of the gums, supporting bone, periodontal ligament and cementum and accumulation of bacterial pathogens, mainly within the periodontal pockets, Periodontal disease commonly refers to inflammatory diseases that are plaque induced i.e. gingivitis and periodontitis, Gingivitis, the moderate stage of disease caused by an accumulation of supragingival plaque and characterized by swelling, light bleeding and redness of the marginal gingiva. Gingivitis is associated with a change in the microflora, shifting from a Gram-positive anaerobic flora to a more Gram negative one. Periodontitis, a more severe stage of periodontal disease, results in the resorption of the alveolar bone and detachment of the periodontal ligament supporting tooth. Periodontitis is an inflammatory response to the overgrowth of anaerobic organisms, Aloe-Vera is one such product exhibiting multiple benefits and has gained considerable importance in clinical research. Since Aloe-Vera extracts shows low intrinsic toxicity along with a wide spectrum of biological actions like antimicrobial, anti-inflammatory, antioxidant, astringent, and other useful properties, it is very useful in Dentistry also, the present study was aimed to formulate site-specific controlled release dental devices containing Aloe Vera for the treatment of periodontal diseases and then evaluated for their physicochemical properties including weight variation, thickness, and estimation of drug content, stability, compatibility, In vitro drug release studies and in vitro antibacterial activity.
