Authors: Hindustan Abdul Ahad, Sreeramulu J, Hima Bindu V, Chitta Suresh Kumar, Kishore Kumar Reddy B, Chandana Rekha V , Sivaji S
develop matrix tablets of Glimepiride with Aloe barbadensis miller leaves mucilage and Povidone and to study its functionality as a matrix forming agent for sustained release tablet formulations, mucilage of Aloe barbadensis miller leaves clinically and experimentally proved anti-diabetic activityand release retardant activity, Glimepiride is an oral hypoglycemic agent, which is commonly prescribed for the treatment of patients with type II diabetes mellitus , It belongs to sulfonylureas drug class. Glimepiride is a weak acid with PKa of 6.2, glimepiride is practically insoluble in water and acidic environment but highly permeable (class 2) according to the Biopharmaceutical classification System (BCS) , the oral absorption is uniform, rapid and complete with nearly 100% bioavailability therapy with Glimepiride is usually initiated with 1 to 2 mg, the pharmacokinetics and dosage schedule supports once daily sustained release formulations for Glimepiride for better control of blood glucose levels to prevent hypoglycemia, enhance clinical efficacy and patient compliance ,the objective of present investigation is to design and evaluate sustained release tablets of Glimepiride using Aloe barbadensis miller leaves mucilage and Povidone combination as release retardant for making sustained release matrix tablets.
