Author Abolfazl Aslani, Alireza Ghannadi, Razieh Raddanipour
design and evaluate the formulation of Aloe vera chewing gum with an appropriate taste and quality with the indications for healing oral wounds, such as lichen planus, mouth sores caused by cancer chemotherapy and mouth abscesses as well as reducing mouth dryness caused by chemotherapy, Aloe vera powder, the carbohydrate content was determined according to mannose and phenolic compounds in terms of gallic acid, chewing gum was cut into pieces of suitable sizes. Weight uniformity, content uniformity, the organoleptic properties evaluation, releasing the active ingredient in the phosphate buffer (pH, 6.8) and taste evaluation were examined by Latin square method, healing properties of Aloe vera improve the skin which is exposed to ultraviolet (UV) and gamma rays. It has antiinflammatory, antiseptic, antiviral, antibacterial, antitumor, moisturizing, antiaging, hypoglycemic, antidiabetic, cytotoxic, and antioxidants effects. It is also used against cardiovascular diseases, pharmaceutical chewing gums are produced in a solid form and a single dose. Their base mainly consists of gum base. This form of medication contains one or more active ingredients that are released by chewing. Pharmaceutical applications of pharmaceutical chewing gums include topical treatment of oral diseases and systemic delivery after absorption through the buccal mucosa or the gastrointestinal route, benefits of chewing gum include consumption without water ,high acceptance by children,[10] low side effects, suitable stability, high bioavailability, rapid onset effect[10] and relieving the mouth dryness by stimulating saliva, formulation of pharmaceutical chewing gums contain pharmaceutical active ingredients, gum bases, fillers, elastomers, plasticizers, softeners, emulsifiers, sweeteners and flavors, factors affecting drug release in this type of dosage form include physicochemical properties of the active ingredient, chewing gum properties and related factors with strength and number of masticatory movements, some of the formulated drugs in the form of chewing gum include fluoride, chlorhexidine, nicotine, aspirin, caffeine, and dimenhydrinate, oral Aloe vera can be used as a wound healer for oral wounds, To heal mouth sores, such as lichen planus, ulcers and abscesses caused by cancer chemotherapy, oral products such as mouthwash are used. Recently, one study examined the effects of 70% Aloe vera extract in the form of mouthwash for the treatment of mucositis caused by radiotherapy and another study examined the effects of 80% Aloe vera extract in the form of mouthwash to treat lichen planus
