Author: Narayana Charyulu Rompicherla , Punam Joshi 1, Amitha Shetty, Kalvatala Sudhakar ,Hawraz Ibrahim M. Amin , Yachana Mishra, Vijay Mishra , Aqel Albutti * and Naif Alhumeed
Topical treatments are a potential therapeutic option for the therapy of osteoarthritis, with significant data supporting the effectiveness and safety of topical formulation. Topical gel formulations may offer an alternative to oral formulations to relieve osteoarthritis (OA) pain while decreasing systemic exposure. Topical capsaicin transemulgel may represent an effective and safe alternative. The transemulgel was prepared from aqueous Aloe vera gel and Carbopol 934 with capsaicin in clove oil emulsion, improved permeability properties. The formulation caused no skin irritation when applied topically, emulsion, capsaicin, arthritis, topical, anti-inflammatory agent, drug delivery, Osteoarthritis is the most common degenerative joint disease, Pathological changes in osteoarthritis joints include destruction of articular cartilage, progressive loss, subchondral bone thickening, osteophytes formation, ligament degeneration, menisci of the knee, and hypertrophy of the joint capsule, treatment includes oral and topical pharmacological agents, patient education, alternative surgery, medicine, physical therapy, and modalities, topical drug delivery has advantages over conventional routes; in particular, it avoids first-pass metabolism, and is a non-invasive mode of drug delivery with a sustained and controlled release profile, Aloe vera (Aloe barbadensis miller), a perennial plant belonging to the family Liliaceae, is used due to its anti-inflammatory, anticancer, antimicrobial, immunomodulatory, and burn healing effects. It has been used in different commercial products, due to its cooling effect, the burning sensation of capsaicin can be reduced by rubbing the skin with Aloe vera gel as a base,therefore, the present research work aimed to develop and evaluate capsaicin transemulgel using Aloe vera gel as a base for the treatment of osteoarthritis
