Author Endang Diyah Ikasari1*, Intan Martha Cahyani2
several factors that influence dissolution test in vitro such as dissolution media. The AIF media (Atrial Intestinal Fluid) and the SIF media (Simulated Intestinal Fluid) media are among the media that can be used in the dissolution test. Mucoadhesive microgranule of ranitidine HCl using a combination polymer of aloe vera powder and carbopol 934P that expands maximally at pH 7.8. The purpose of this study was to determine the dissolution profile of mucoadhesive microgranule of ranitidine HCl in AIF (Artificial Intestinal Fluid) pH 7.8 and SIF (Simulated Intestinal Fluid) pH 7.8 with a line of identification approach, the method of making granules used is wet granulation. Data analysis using Statistic Product and Service Solution (SPSS) 16.0 with Test, the test results showed that the dissolution profile of AIF media followed Higuchi model while in SIF media following release model of order 1. Mechanism of release of mucoadhesive microgranule of ranitidine HCl on SIF media was better than AIF media. Media type significantly influence dissolution test, Ranitidine is a class of Biopharmaceutics Classification System (BCS) class III which has high solubility and low permeability,
