Author Talmadge J, Chavez J, Jacobs L, et al.
Aloe vera L. plant have demonstrated multiple clinical activities, hematopoietic activities of Aloe vera extracts , organ-specific in vitro molecular profile , Preclinical studies have shown that such carbohydrate-containing extracts promote wound repair, augment reticuloendothelial function, modulate immune responses , and function as an anti-neoplastic, stimulate hematopoiesis, Aloe vera gels are composed predominantly of insoluble plant cell wall material, soluble carbohydrates, calcium malate, and a small amount of protein , carbohydrates are composed of long-chain polydispersed h-(1,4)-linked acetylated polymannan with interspersed O-acetyl groups and a mannose monomer/acetyl ratio of approximately 1:1. Pharmacological properties appear to be mainly mediated by the activation of monocytes-macrophages, and extracts of Aloe vera have been reported to enhance the release of cytokines, including interleukin (IL)-1, IL-2, IL-6, interferon (IFN), granulocyte/monocyte-colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF) in vitro, augmentation of reticuloendothelial functions, humoral and cell-mediated immune response, tumor therapy, and hematopoietic proliferation and differentiation, These activities are thought to be secondary to the stimulation of histiocytic lineage cells, resulting in increased secretion of cytokines and enhanced cellular function, Acemannan has been shown to activate macrophages in vitro and vivo
