Author Teerapong Rattananukrom , Aisawan Petchlorlian ,Iyarit Thaipisuttikul and Mongkhon Sompornrattanaphan
The skin has a multifactorial aging process, oxidative damage, skins antioxidant system tends to weaken with age, alteration of the intestinal bacteria, microbial dysbiosis, skin interactome , genome-microbiome-exposome, delay skin aging , human microbiomes affect skin aging , Probiotics-based products, add-on treatment of many dermatologic conditions, skin anti-aging purposes , therapeutic options, , dermatological and cosmetologically treatments, aging process, Biologic aging is a process occurring at the cellular and molecular level, deterioration in the function and structure of all of the organ systems, live a longer and healthier life, live a longer and healthier life, ingestion of an unbalanced diet, Molecular mechanism of aging, cellular aging, Cellular senescence, skin has a multifactorial aging process, chronologic skin aging, genetic, hormones, and cellular metabolic changes, metabolites from the gut and skin microbiome, soft tissue changes including decreased collagen production, lower amounts of lipids, epidermal thinning, and the loss of subcutaneous fat, aged skin appears dry and pale with fine wrinkles and increased laxity, Facial aging , soft tissue changes, facial bone resorption, and recession, ultraviolet radiation, skin manifests deep wrinkles, laxity, coarseness, increased fragility, and multiple telangiectasias, photodamaged skin may exhibit depigmentation such as darkening and mottled pigmentation, solar elastosis, reduced number of fibroblasts, and decreased amount of extracellular matrix ,weak skins antioxidant system , collagen degradation, oxidative stress , Oxidative insult, skin disease or systemic disease , imbalance of commensals and pathogens, microorganisms are variably present at the surface compared with deeper skin layers, capture of skin microbiota , distribution of microorganisms in the skin, microbial diversity and a greater inter-individual variation in microbiota composition in old people, longevity is positively associated with an abundance of short-chain fatty acid (SCFA) producers, signature for longevity, good immunological and metabolic health-related bacteria, decreased levels of Bifidobacterium, Bacteroides, and Enterobacteriaceae, and increase Clostridium spp. Levels, aging-associated differences in gut microbiota , according to age-related changes in microbiome diversity, loss of diversity in the core microbiota groups.
