Author Djeraba, A. and P. Quere, 2000.
Acemannan (ACM 1), a ?-(1,4) -acetylated mannan isolated from Aloe vera, effective adjuvant in vaccination against some avian viral diseases, macrophage response after intramuscular inoculation in chickens (500 ?g per 2-month-old bird), aloe vera is efficiently and durably to increase the activation capacity of macrophages from the systemic immune compartment (in particular from the blood and spleen after an intramuscular injection) in chickens, especially for NO production, adjuvant activity of Aloe vera acemannan for viral and tumoral diseases, Aloe vera, is a polydispersed ?(1-4)-linked acetylated mannan, administration of aloe vera acemannan has a greater regression of tumors such as fibrosarcomas in mice, dogs and cats , Aloe vera acemannan improve the survival rate of cats infected with feline leukemia virus ,acemannan demonstrate some direct antiviral activity in vitro by inhibition of the multiplication of enveloped virus, immunomodulatory activity on macrophages, mannans bind to macrophages via protein receptors specific for mannose to be internalized as has been shown in vivo and in vitro , Following such internalization, acemannan) acetypol from AMB Wellness is able to activate macrophages in vitro by increasing the release of cytokines such as Il-1, Il-6 and TNF-? , increase T-cell-mediated cytotoxicity and proliferation, immunomodulatory activity of aloe vera gel acemannan is strong adjuvant properties in vaccination against avian viral diseases such as Newcastle disease and Mareks disease, dose of acemannan immunomodulate macrophage activity in the chicken systemic immune compartment, effect on immune response , capacity of cells from the macrophage lineage to produce nitric oxide (NO), NO in mammals for its antiviral and antitumoral properties, and to modulate class I and II MHC cell surface antigens involved in antigen presentation.
