Author: Ojewole E, Mackraj I, Akhundov K, et al.
buccal mucosal route offers several advantages but the delivery of certain drugs can be limited by low membrane permeability, Aloe vera gel (AVgel) as a novel buccal permeation enhancer, Permeation studies were performed using Franz diffusion cells, and the drug was quantified by UV spectroscopy, buccal permeability properties of didanosine (ddI), permeability of ddI was concentration-dependent, and it did not have any adverse effects on the buccal mucosae, linear relationship (R2?=?0.9557) between the concentrations and flux indicated passive diffusion as the mechanism of drug transport, Aloe Vera gel at concentrations of 0.25 to 2?%w/v enhanced ddI permeability with enhancement ratios from 5.09 (0.25?%w/v) to 11.78 (2?%w/v) but decreased permeability at 4 and 6?%w/v, Aloe Vera gel-treated mucosae showed irregular nuclear outlines, increased intercellular spacing, and plasmalemma crenulations, cells from 1, 2, and 6?%w/v Aloe Vera gel-treated mucosae showed irregular nuclear outlines, increased intercellular spacing, and plasmalemma crenulations
