Author: J. Hochman, P. Artursson
therapeutic agents to exert their pharmacological effects, cross the biological membranes into the systemic circulation and reach the site of action, Drugs cross the membranes by one of two pathways; paracellular or transcellular, drugs are transported transcellularly, physiocochemical properties, The paracellular pathway is governed by the tight junctions, absorption enhancers for paracellular drug transport enhancement, drug delivery improvement, tight junctions are a multiple unit structure composed of multiprotein complex , drugs across the intestinal epithelium and the blood brain barrier endothelium, mucosal adjuvant, drug delivery of therapeutic agents.