Author: Na, K.; Lkhagva-Yondon, E.; Kim, M.; Lim, Y.R.; Shin, E.; Lee, C.K.; Jeon, M.S.
Atopic dermatitis (AD) is a chronic inflammatory skin disease, dry itchy skin that results from defects in the epidermal barrier function. Aloe vera is used widely to promote general health and is administered topically to treat skin conditions such as eczema, burns and wounds, oral administration of processed A vera gel (PAG) containing low molecular weight Aloe polysaccharides to treat ovalbumin (OVA)-induced Atopic dermatitis in mice. Oral administration of PAG suppressed total and OVA-specific IgE production in sera and decreased the epidermal thickness of skin, oral administration of polysaccharides Aloe vera Gel ameliorated Atopic dermatitis , normalized tight junction gene expression and suppressed inflammatory cytokines in Atopic dermatitis skin, Atopic dermatitis (AD) is a chronic inflammatory skin disorder that results from defects in the epidermal barrier and immune dysfunction, complex pathophysiology of Atopic dermatitis is known to include genetic risk factors, environmental triggers and dysregulation of innate and adaptive immunity, Current understanding of the aetiology of AD is that disruption of the epidermal barrier leads to increased permeability of the epidermis, pathological skin inflammation and percutaneous sensitization to allergens, One of the therapeutic approaches aims to maintain or improve epidermal barrier function to ameliorate AD. The skin is composed of two barrier structures, the stratum corneum (SC) and tight junctions (TJs) that provide a physical barrier against dehydration and environmental challenges, Aloe vera has been used both as a therapeutic and dietary health supplement in the treatment of various diseases, It is known to have immunoregulatory and skin moisturizing properties, notably, A vera polysaccharides have been shown to modulate immunity in both humans and mice, topical application of polysaccharides Aloe vera gel extract helped treat the AD, It is not only used topically, but also has been administered orally via liquid formulations, tablets and capsules, however, the effects of orally administered Aloe polysaccharides in Atopic dermatitis AD-related diseases have not been fully elucidated, the average molecular weight of native polysaccharides in A vera gel is 2000 kDa or higher. We used polysaccharides Aloe vera gel (PAG), which has polysaccharides sized 5-400 kDa , polysaccharides Aloe vera gel can enhance the immunomodulatory activity of the polysaccharide, oral administration polysaccharides Aloe vera gel in ovalbumin (OVA)-induced AD mouse model and investigated how these molecules affect skin barrier function, including the genes encoding the tight junction proteins TJP-1, claudin-1 and claudin-8, and cytokines that include IL-4 and IL-17A,
