Author: W. Gerber, D. Steyn, Awie Kotzé, H. Svitina, C. Weldon, J. Hamman
nasal route of drug administration offers an alternative way for oral drug delivery and has the benefit of avoiding first-pass metabolism through drug delivery directly into the systemic circulation, drug absorption enhancing effects of selected aloe, Pharmacokinetic modulation, drug-herb interactions, Substances responsible for the enhancement of pharmacokinetic profiles (i.e. bioenhancers) may be substrates, inhibitors and/or inducers of absorption, metabolism, distribution and excretion, co-administered drug bioavailability, applicable to drugs with unfavourable physico-chemical properties such as large molecular weight drugs that experience difficulty to diffuse across biological membranes, as well as drugs that exhibit a high affinity for efflux transporters or metabolic enzymes, drug membrane permeation enhancing effects are Aloe vera, Aloe Vera Gel have the ability to open tight junctions between adjacent epithelial cells and thereby increase drug permeation across the intestinal epithelium, buccal epithelium and the skin, nasal route of drug administration facilitate delivery of poorly bioavailable drugs, nasal administration, drugs are delivered directly into the systemic circulation, thereby circumventing first-pass metabolism, when grown under ALI conditions, the RPMI 2650 cell line presents as a uniform multi-layered cell formation that expresses tight-junctions, multi-drug resistance proteins and transepithelial resistance and permeability values similar to that of excised human nasal mucosa, Aloe Vera Gel gel increased the transport of different molecules in a concentration dependent manner across other epithelial membranes including intestinal and buccal mucosal surfaces, functional excipients and/or bioenhancers,
