Author: Di Colo G, Zambito Y, Zaino C.
drug delivery ,absorption enhancer, permeation enhancer , polymeric biomaterials, polymer synthesis, chitosan, paracellular, transport transcellular, transport tight junction , transmucosal drug administration across nasal, buccal, and ocular mucosae is noninvasive, eliminates hepatic first?pass metabolism and harsh environmental conditions, allows rapid onset, and further, mucosal surfaces are readily accessible, hydrophilic drugs, such as peptides and proteins, are poorly permeable across the epithelium, which results in insufficient bioavailability, reversible modifications of epithelial barrier structure by permeation enhancers are required, Low molecular weight enhancers generally have physicochemical characteristics favoring their own absorption, polymeric transmucosal penetration?enhancers, intestinal permeation enhancers, synthesis and characterization of polymers, their effectiveness in enhancing the absorption of different drugs across different epithelium types, their mechanism of action and structure?efficacy relationship
