Author Endang Diyah Ikasari*, Anang Budi Utomo, Hanny Setyowati, Salasa Ayu Trisnawati
Ranitidine hydrochloride is a competitive inhibitor of histamine H2receptors, drug of choice in the treatment of ulcer, The drug has a short biological half-life of approximately 23 hours, thus a sustained release dosage form of ranitidine HCl is desirable. The aim of this study was to formulate and in vitro evaluate microgranules with ranitidine HCl, Microgranules were prepared by the wet granulation method using aloe vera powder as bio adhesive polymer. Increasing concentration of aloe vera powder results decreasing of flow rate, improving of moisture content, swelling index, in vitro bio adhesive, and dissolution efficiency, results indicated that aloe vera powder is a suitable polymer for developing a sustained-release dosage form of ranitidine HCl for local delivery in the gastrointestinal tract, The polymers used in the mucoadhesive dosage form of ranitidine HCl are a combination of aloe vera polymer 27.34% and Carbopol 934P 7.62% , mucoadhesive microgranule of ranitidine HCl undergoes a slow drug release at pH 7.8 because the gel expands optimally so that the release rate of the drug can be controlled. Many factors that influence dissolution test in vitro include dissolution media
