Author B. A. González, R. Domínguez-Espinosa, B. R. Alcocer

Aloe vera gel, probiotic strains, fermentation parameters, strains, high concentration of health promoting bacteria, drink with a pleasant taste, intake of probiotic agents, nutrients and nutraceutical agents,

Author Md. Rayhan Mahmud Sharmin Akter ,Sanjida Khanam Tamanna,L Mazumder ,Israt Zahan Esti ,Sanchita Banerjee ,Sumona Akter ,Md. Rakibul Hasan ,Mrityunjoy Acharjee ,Md. Sajjad Hossain m Anna Maria Pirttilä

gut-skin homeostasis, skin diseases, gut microbiome affects skin health, gut microbiome on skin conditions, gastrointestinal health, gut dysbiosis, skin disease, probiotics, prebiotics, skin-gut axis, dietary components, complex immunological and neuroendocrine organs, skin serves as a defensive obstruction against injuries and microbial assault, health and longevity of the host, Several dermatologic conditions, such as acne, atopic dermatitis, psoriasis, and rosacea are linked with intestinal dysbiosis, microbial ecology of skin, gut tissues , dietary products and skin dysbiosis , dietary effects on skin conditions, stratum corneum, hair follicles, and sebaceous glands, normal gut harbors bacterial genus such as Bacillus, Lactobacillus, Enterococcus, Clostridium, and Ruminococcus, role of gut microbiome in epithelial cell renewal and intestinal integrity regulation, immune protective responses, trans-epithelial dendrites, Disruption of gut integrity, and an imbalance within microbial communities can have a significant impact on the overall homeostasis of skin, butyrate wanes the intestinal barrier permeability and enhances epithelial barrier integrity, keep the epithelial barrier intact.

Author: Tajendra Pal Singh, Santosh Kumari, Swati Sethi

Aloe vera (Aloe vera spp.) juice for preparation of lassi, chemical composition, health foods of dairy origin, fermented products, valuable nutrients, fermentation provides food safety, portability and novelty for the consumer, fermented milk beverage

Author S. A. Hussain, G. R. Patil, R. B. Singh

Aloe vera, lassi, probiotics, shelf-life, principal component analysis, Different strains of L. paracasei, yoghurt, Kefir and other fermented milks, Aloe polysaccharides, human colonic bacteria indicating, functional food market, Aloe vera used as a supplement

Author Ajay Kumar, Shaik Abdul Hussain , Writdhama Prasad, Ashish Kumar Singh , R.R.B.Singh

storage stability of Aloe vera, maintain higher immunity and health status, functional foods, nutraceuticals , Fermented products, improving the well-being, Health attributes, functional ingredients, supplementing with probiotics, Lactobacillus gasseri SBT2055, probiotics, antimicrobial, antimutagenic, anticarcinogenic and antihypertensive attributes, food matrix, probiotic bacteria, probiotic fermented beverages, oxidative potency, Intense sourness, long shelf-life probiotic fermented dairy products, aloe health promoting nutrients, functional cultured buttermilk, probiotic culture, herbal ingredients

Author Eric Banan-MwineDaliriaByong H.Leeabc

scientists, synbiotics, health claims, healthy microbiota, molecular advancement, Probiotic; Heath benefits; Bile salt hydrolase; Dysbiosis; Microbiome, vaginal cavity, metabolic, bacterial community composition, bacterial populations, disease symptoms, prevention of diseases than cure and hence, human gut microbiota, function of the cells, gut health, to immune support, skin health, cholesterol control

Author Deepak Mudgil, Sheweta Barak, Palak Darji

aloe therapeutic properties, basis of sensory evaluation and analysed for moisture, pH, instrumental colour , textural profile properties, developed product, Aloe vera juice, burfi, characterization, Ice cream was preparation, Aloe vera in yogurt, probiotics drinks, good taste, flavoured milk fortified with Aloe vera gel, fortification of dairy products , fortification of cultured buttermilk, development of a novel and functional herbal khoa burfi, Aloe vera juice addition had a non-significant effect on the color and appearance scores up, Aloe vera juice at 15% level produce drinking yogurt

Author Melania Casertano, Vincenzo Fogliano, Danilo Ercolinia

Nervous system disorders, beneficial effects of the probiotics on the gut and the gut-brain axis, Psychobiotics are a probiotic strain capable to affect the gut-brain axis, health-promoting properties, bioactive peptides, unsaturated fatty acids, minerals and vitamins, prebiotics, and probiotics , Bifidobacterium animalis subspecies lactis Bl-04, anti-diabetic/obese potential by Lactobacillus johnsonni 3121, Lactobacillus rhamnosus 86, and Lactobacillus casei YRL577, treatment of arthritis, pouchitis, ulcerative colitis, Crohn disease by Lactobacillus casei, Lactococcus lactis NCDO 2118, anti-cancer effects of Saccharomyces cerevisiae and engineered Escherichia coli Nissle 1917 (EcN), management of COVID-19 by Bifidobacteria (Bozkurt and Quigley 2020), and fertility improving properties of Lactobacillus plantarum 2621 , The term “Psychobiotics” refers to probiotics, prebiotics, and all microbiota-targeted interventions that can manipulate microbiota-gut-brain signals and have positive effects on neurological functions such as mood, cognition, and anxiety, metabolites including tryptophan and short-chain fatty acids (SCFAs), effects of SCFAs on the cellular system are mediated through immune system and endocrine pathways as well as neural and humoral route, SCFAs activate free fatty acid receptors and interact with immune and intestinal epithelial cells, which can affect the safety and function of the intestinal mucosa, microbiome profile and metabolism properties, probiotics effect mainly enhance gut health.

Author Bridgeman SC, Northrop W, Melton PE, Ellison GC, Newsholme P, Mamotte CDS.

Butyrate, the microbiome, metabolic síndrome, mechanisms of action, epigenetic effects, butyrate supplementation, cell-based models, obesity, dyslipidaemia, insulin resistance, hyperglycemia and hypertension, Butyrate’s positive metabolic effects

Author: Chun-Hui, L.; Chang-Hai, W.; Zhi-Liang, X.; Yi, W.

Aloe barbadensis Miller, Sea water irrigation, Polysaccharide, Antioxidant activities, Free radicals

Author Russell, W.R.; Hoyles, L.; Flint, H.J.; Dumas, M.E.

microbial–mammalian metabolic axis, Bacterial fermentation of carbohydrates and proteins, metabolites, fibre-related phytochemicals, gut–liver axis, role of the gut microbiota in choline deficiency, insulin resistance, methylamines, biochemical transformations, Metabolites formed by the gut microbiota, fermentation of plant-derived carbohydrates, concomitant changes in the gut microbiota, acetate, succinate, propionate, butyrate, formate, lactate, ethanol, hydrogen and CO2, development of fatty liver in human, inflammasomes, murine insulin-resistance phenotypes, methylamine metabolism

Author: Imtinene Hamdeniae, Islem Yanguib, Adnen Sanaac, Slim Slimc ,Mounir Louhaichid Chokri , Messaoudb Abdennacer , Boulilae ,Taoufik Bettaieba,

Supplementation, in-vitro culture médium, Aloe vera gel, micropropagation, A. vera plants, organic supplement, In vitro propagation , Aloe vera leaf gel , Biochemical activities, Antioxydant assays, Genetic stability , Molecular markers

Author Svitina, H.; Swanepoel, R.; Rossouw, J.; Netshimbupfe, H.; Gouws, C.; Hamman, J.

Author: Madboly, L.A.; Kabbash, A.; Yassin, A.M.; Yagi

Diet is a natural source of butyrate through the fermentation of non-digestive fiber, such as acemannan in Aloe vera gel, immune modulation and colorectal cancer prevention, GC/MSD análisis, endophytic microbiota of Aloe vera gel , Bacillus cereus, B. licheniformis, Lactobacillus paralimentarium, Yeast: Clavispora lusitaniae, regulate the inflammatory responses , induced reactive oxygen species, Aloe vera gel juice and microbiota, beneficial effects of butyrate in intestinal colon and on colitis, innovative concept of symbiotics

Author Maryam Bahrami , Seyed Ziaeddin Hosseini Mazhari , Zeinab Ebrahimzadeh Mousav

physicochemical, textural pro?le, microbial, antioxidant, and sensory characteristics of the produced yoghurt containing Aloe vera, Aloe vera gel concentration, health bene?t to the consumers, enriched with probiotic bacteria, probiotic products with Aloe vera gel provide health advantages,

Author R. B. Cuvas-Limón, Montañez Sáenz Julio, Contreras Esquivel Juan Carlos, Cruz Hernández Mario, Solange I. Mussatto and Belmares-Cerda Ruth

probiotics , health benefits, lactose intolerance, natural resistance to infectious , disease, gastrointestinal tract, suppression of cancer, an antidiabetic agent, decrease in serum cholesterol levels settings, gastrointestinal disorders, health benefits, probiotics, prebiotics or functional foods, aloe vera promotes a health benefit on the host, plants and fruits, probiotic activity, antimicrobial activity, improvement of the intestinal barrier , immunomodulation, health benefit associated with modulation of the gut microbiota, aloe vera is considered healthful product ,functional ingredient is a modified food or food ingredient that may provide a health benefit beyond that of the traditional nutrients it contains, Plant-based products, probiotic dairy foods, probiotic and prebiotic Aloe vera enriched drink using a fermentative process, microorganisms, substrate and the prebiotic – probiotic biotransformation affecting the lactic acid formation

Author: Yunes Panahia Amirhossein Sahebkare

Aloe vera, Gastroesophageal reflux disease , Complementary therapies , Treatment outcome, Randomized controlled trial, GERD symptoms

Author Sukhvir Kaur*, Harjot Pal Kaur and Parveen Gupta.

dairy products, dietary supplements, Aloe vera fortified probiotic yoghurt, host intestinal microbial balance, formulation functional ingredients, dairy foods, fermented milk products, nutraceuticals, disease conditions, bio-yoghurt, medicinal foods, aloe vera as functional agent, probiotic foods.

• Author Bahram G, Malekshahi H, Miraghaee S, Madani H, Babaei A, Monammadi B, Hatami R.

Aloe Vera Gel, Acetic Acid, Ulcerative Colitis, weight loss, diarrhea, ulcers, inflammation, Gerald classification system score, food intake, gastrointestinal mucosa, disease, immune regulation, genetic factors, infectious agents, oxidative stress , environmental factor, gastrointestinal disorders, constipation, hemorrhoids, colitis, colon problems

Author Javad Sharifi-Rad, Célia F. Rodrigues,Zorica Stojanovi?-Radi?,Marina Dimitrijevi?, Ana Aleksi?, Katarzyna Neffe-Skoci?ska, Dorota Zieli?ska,4 Danuta Ko?o?yn-Krajewska, Bahare Salehi, Selvaraj Milton Prabu,Francine Schutz, Anca Oana Docea, Natália Martins, and Daniela Calina

dietary products, supplements, diversity of bacteria and yeast strains, delivery systems of probiotics, intestinal flora, beneficial effects of the administration of probiotics , nutrition; lifestyle; probiotic properties; evidence based-medicine; mechanisms; clinical studies; safety, development of food science and nutrition, biologically active molecules, balanced nutritional value, Metabolomics , research , healthy microbiota, regulate the immune response, improve the function of the intestinal mucosal barrier, increase the stability or promote the recovery of the commensal microflora when it is disturbed, modulate the expression of host genes, release functional proteins such as lactase or natural enzymes, and decrease the adhesion of pathogens , Health and Nutrition Properties of Probiotics, symbiotics, optimal repopulation of the flora, preventive purposes, microbiota , beneficial microorganisms , probiotic preparations

Author Yan Shi, Kehong Wei, Jiachen Lu, Jing Wei, Xiaojing Hu, and Tingtao Chen

aloe vera fermentation, healing-promotion effects , microbial compositions, healing time , clinical applications, saliva microbiota, fermentation by probiotics, health-modulation, metabolites , probiotics and aloe vera , lactic acid, Oral Microbial Community

Author Mariano Del Toro-Barbosa, Alejandra Hurtado-Romero, Luis Eduardo Garcia-Amezquita, and Tomás García-Cayuela

gut-brain-microbiota axis bilateral communication system that enables gut microbes to interact with the brain, and the latter with the gut, Gut bacteria influence behavior, depression and anxiety symptoms are directly associated with alterations in the microbiota, Psychobiotics are defined as probiotics that confer mental health benefits to the host, psychobiotic potential, psychobiotic potential of several bacterial strains and fermented products, restore mental health, life quality, depression decrease productivity at work, serious mood disorder, sad and anxious mood, pessimism, irritability, fatigue, alterations in sleeping patterns, and suicidal thoughts, interaction of psychological, environmental, genetic, and biological factors, intestinal and mental disorders coexisting, central nervous system and the gastrointestinal tract, central nervous system and the gastrointestinal tract, gut microbiota exerts, enteric microbiome plays a key role in the gut-brain axis communication, involvement of neural, endocrine, immune, and metabolic systems, cognitive functions, alterations in the microbiota, Gut microbial dysbiosis is often connected to aberrant immune responses that include the overproduction of inflammatory cytokines, calibrate the innate and adaptive responses, metabolites they produce can pass through this barrier and enter and accumulate in the host’s circulatory system, where they are able to stimulate cells from the immune system

Author: Julio Plaza-Diaz, Francisco Javier Ruiz-Ojeda, Mercedes Gil-Campos, and Angel Gil

probiotics therapeutic options, modification of the gut microbiota, competitive adherence to the mucosa and epithelium, strengthening of the gut epithelial barrier and modulation of the immune system to convey an advantage to the host, probiotics communicate with the host by pattern recognition receptors, uncover novel probiotic functions, probiotic modes of action , gastrointestinal microbiota, secretion of antimicrobial substances, competitive adherence to the mucosa and epithelium, strengthening of the gut epithelial barrier and modulation of the immune system, luminal contents , tight junction, competitive exclusion, selective metabolites

Author: Marta Sánchez, Elena González-Burgos, Irene Iglesias, and M. Pilar Gómez-Serranillos

Research on this medicinal plant, active compounds, aloe studies, anti-cancer action, skin and digestive protective activity, and antimicrobial properties, Clinical trials, effect of relevant metabolites, pharmacology; extracts; isolated compounds,

Author Slavin, J.

health benefits, intakes of dietary fiber, gut health, physiological effects, oligosaccharides, fermented ingredient, gastrointestinal microflora, host well-bring and health, colon ferment the gut microflora, oligofructose, beneficial bacterial genus, galactooligosaccharides (GOS), transgalactooligosaccharides (TOS), polydextrose, wheat dextrin, acacia gum, psyllium, banana, whole grain wheat, and whole grain corn also have prebiotic effects, gastrointestinal microflora, different species of bacteria reside in the colon with microbial populations, provide important support for diet

Author Susan L. Prescott,Danica-Lea Larcombe, Alan C. Logan, Christina West, Wesley Burks, Luis Caraballo, Michael Levin, Eddie Van Etten, Pierre Horwitz, Anita Kozyrskyj, and Dianne E Campbell

disturbances of the stratum corneum have been noted in allergic diseases (eczema and food allergy), psoriasis, rosacea, acne vulgaris and with the skin aging process, epidermal keratinocytes , Skin barrier structure , Microbiota, Inflammation, Allergy, Cytokines, Biodiversity, Colonization, Antibiotics, DOHaD, Ecosystems, Prevention, NCDs, Caesarean section, Pregnancy, microbial habitats, skin ecosystem , body surfaces, microbial-immune interactions in the skin , healthy tissue homeostasis , defects in skin integrity, skin ecology, skin aloe vera treatment, essential metabolic roles in a particular cutaneous niche, Disruptions of the epidermal barrier , skin aging process, stratum corneum represents an essential line of photoprotection, skin microbiome, cutaneous ecosystems, holobiont , strain-level identification , specific skin site, moist versus dry skin areas

Author: Weronika Majchrzak, Ilona Motyl, Krzysztof ?migielski

bioferments; natural cosmetics; fermentation; bioactive compounds, innovative ingredients, bioactivity, bioavailability, fermented plant, y bioferments are made from plant-based raw materials, Fermentation increases the biochemical and physiological activity of the substrate by converting high-molecular compounds into low-molecular structures, making fermented raw materials more compatible compared to unfermented raw materials, cosmetic preparations, fermentation processes to obtain biomolecule-rich cosmetic ingredients, microbial strains, Cosmetics,bioferments formulation, marketed as natural or more health-friendly cosmetics.

Author by Hyeonwoo Lee ,Woonyong Choi ,Hyangseon Ro ,Gyurae Kim and Hyeonyong Lee

leaf skin of Aloe vera; mitochondrial activities; skin antiaging; lactic acid fermentation, antiaging effects of Aloe vera leaf skin fermented by Lactobacillus plantarum on UVb-irradiated skin fibroblasts, reactive oxygen species (ROS), DPPH free radical scavenging activities, bioactive substances derived from the fermentation process, collagen gene expression, aloe increases the activation of mitochondria and inhibits the photo-aging of UVb-irradiated skin fibroblasts.

Author J. H. Cho

Aloe-fermented product, Gastrointestinal function, Inflammatory dowel disease, Trinitrobenzene sulfonic acid solution (TNBS),

Author Elena Puertollano , Sofia Kolida, Parveen Yaqoob

gut microbiota, essential mediator in the pathophysiology of obesity and related metabolic disorders, metabolite profiles, host metabolism, gut microbial metabolites, diet-gut microbiota-host homeostasis axis, metabolic conditions, novel therapeutic targets, obesity, dietary fiber, metabolic disorder, disrupted dynamics of energy homeostasis, pathogenesis of obesity, integral mediator in diet-induced obesity, micronutrients, regulate host energy metabolism.

Author Fang Yan and D. Brent Polk

correlation of dysbiosis with diseases, chronic intestinal conditions, inflammatory bowel disease , promote intestinal health , intestinal homeostasis, mechanisms of probiotic action, probiotics and probiotic-derived functional factors, metabolites by probiotics,  human gastrointestinal tract, nutrient-rich and metabolically favorable environment for the microbiota, functional maturation of the gastrointestinal tract, induction of immunotolerance, neurodevelopment and homeostasis of intestinal epithelial cells, and functions of the immune and nervous systems in adulthood , physiological responses, gut–brain axis,  gut reduced anxiety-like behavior, probiotic supplementation

Authors:Chang Liu, Peng Du, Yahui Guo, Yunfei Xie

acetyl groups, Aloe Polysaccharides increased the concentration of Short chain fatty acids, health benefits of aloe polysaccharide, Aloe Polysaccharides modulate the gut microbiota and the relationship between microbiota and Short chain fatty acids, aloe acetypol acemannan supplementation, Ultrasound extraction, In-depth bioinformatics analysis

Author Chao-Yue Su1, Zuo-Liang Zheng, Cun-Wu Chen1, Bao-Wei Lu and Dong Liu

Unhealthy diet, high-fat diet (HFD) intake, metabolic disorders, metabolic diseases reduce the quality of life, and induce premature death worldwide, effective therapeutic strategy, metabolic dysfunctions, aloe vera gel Polysaccharides are polymeric carbohydrate macromolecules and sources of fermentable dietary fiber, biological activities in the prevention, natural aloe polysaccharides are among the most potent modulators of the gut microbiota composition, critical role of gut microbiota human, Gut microbiota is considered as an invisible “forgotten organ” of human beings, host physiology, genomic blueprint of human gut microbiota, chronic metabolic disorders, central obesity, insulin resistance, hyperlipidaemia, and hypertension ,modulating “diet-microbiota-immune” axis, administration of specific metabolites, prebiotics-like activities of polysaccharides, polysaccharides are primary modulators of the function and composition of gut microbiota

Author Yue Liu, Jiaqi Wang and Changxin

human gastrointestinal tract , interacts with the mucosal immune system closely, Gut microbiota plays a significant role in maintaining host health, d supply various nutrients, regulate energy balance, modulate the immune response, defense against pathogens, maintaining a favourable equilibrium of gut microbiota through modulating bacteria composition, diversity, and their activity is beneficial to host health, probiotics and pre-biotics could indirectly regulate microbiota and immune response, post-biotics, as the bioactive metabolites, produced by gut microbiota, and/or cell-wall components released by probiotics, inhibit pathogen growth, maintain microbiota balance, regulate an immune response, health-promoting microorganisms, balance of the gastrointestinal microbiome, Probiotics could modulate human intestinal bacteria, inhibiting harmful bacteria, stimulating beneficial bacteria, lactic acid bacteria, toll-like receptors, Pattern recognition receptors, bifidobacteria , substrate that is selectively utilised by host microorganisms conferring a health Benefit,postbiotics, maintain homeostasis of intestinal microbiota and improve intestinal health

Author Hyang Seon Ro,Hyun Jun Jang,Gyu Rae Kim,Sang Jin Park, Hyeon Yong Lee

juice-type product of Aloe, anti-skin wrinkling effects, lactic acid fermentation with Lactobacillus plantarum, fermentation process, activated human fibroblast cells , total polysaccharides, enhancing skin regeneration, easy penetration of the small molecules, active components from natural resources, generally recognized as safe (GRAS) by the FDA for food purposes, improve the cosmeceutical activities, enhance the biological activities of aloe vera, aloe in cosmetic applications, Extracts, production of collagen by human fibroblast cells, substrate solution, medium , inoculation, aloe vera gel range of concentrations, active cells , ellular mitochondria 

Author Anna Chizhayeva , Yelena Oleinikova , , Margarita Saubenova , Amankeldy Sadanov , Alma Amangeldi , Aida Aitzhanova , Aigul Alybaeva , Makpal Yelubaeva

Microbiota imbalance , metabolic diseases , dysbiosis for bad human nutrition, nutritional and biological value, base of functional beverages is aloe fermented, metabiotics , functional properties , host organism, fermented by probiotics, bioactive natural plant ingredients, microbiome , human metagenome, intestinal microbiota, digestive tract , species of microorganisms, molecular and genetic research, Human Intestinal Tract Metagenomics, minimal gut genoma, enterotype microflora, regulates metabolic processes, ‘tension’ of human immunity, neuroactive molecules, stress response, digestive tract cells , neuroactive molecules—serotonin, melatonin-,dysbiotic conditions, human diet , intestinal permeability, mucosal immune function, intestinal mobility and sensitivity, and intestinal nervous system activity, physiologically functional food ingredients.

Author: Parmjit S. Panesar and Chetan Shinde

dietary supplements, processed foods, improving the host intestinal microbial balance, developing new probiotics formulations, neutraceutical industry, functional ingredients in the dairy foods, preparation and development Aloe vera fortified probiotic yoghurt,

Authors: Avinash Tungala, Ajay J.Y, Pradeep Gajula, Dinesh. J, Deepak kumar.

Lactic acid bacteria, malate, lactate conversión, Bio chemical identification, Morphological, Natural defense system enhancers, acemannan,

Jinyoung Kim, Kathryn J Burton-Pimentel, Charlotte Fleuti, Carola Blaser, Valentin Scherz, René Badertscher, Corinne Marmonier, Noëlle Lyon-Belgy, Aurélie Caille, Véronique Pidou, Adeline Blot, Claire Bertelli, Jérémie David, Ueli Bütikofer, Gilbert Greub, Dominique Dardevet, Sergio Polakof, Guy Vergères.

foods; dairy products; fermented food; gut microbiota; ageing; lipids/free fatty acids

Author Sabeena Manzoor M.Tech, Shoib Mohmad Wani M.S, Sajad Ahmad Mir Ph.D, DanishRizwanM.Tech.b

Aloe vera juice, functional beverage ,probiotics, prebiotics, SCFA, phenolic compounds, fermented composition, dairyceuticals,

Author Karolina Chilicka , Iwona Dzie ´ndziora-Urbi ´nska , Renata Szygu?a Binnaz Asanova and Danuta Nowicka

microbiome; skin microflora; probiotics; skin care, Acne vulgaris is a disease characterised by skin eruptions such as whiteheads, blackheads, pustules, papules, and cysts, inflammatory lesions, Topical agents, microbiome (microbiota) describes the entirety of microorganisms present in a given habitat, Bacterial composition depends on the use of cosmetics, environmental factors, profession, exposure to UV radiation, antibiotics, and humidity, dysfunction of the skin barrier function, surface of the skin, proper immunity of the organism and defence by microorganisms, thus determining tolerance to substances supplied to the human body with food, leading to an immune response, microbiota also modifies the production of short-chain fatty acids (SCFAs), which fulfil many functions, e.g., nourishing intestinal cells and modulating brain activity, propionic acid, Externally Used Probiotics in Dermatology and Cosmetology, probiotic effects are Lactobacillus and Bifidobacterium, Probiotics may be used product categories such as drugs, cosmetics, dietary supplements, and food and food additives, The International Cooperation on Cosmetics Regulation (ICCR) developed categories of microbiome-related products that included probiotics and postbiotics, . The action of probiotics is based on binding them to the epidermal surface, inhibiting pathogens, producing antimicrobial substances, and increasing immunomodulatory properties. Immunomodulatory properties transformthe probiotic cosmetic into a preparation that can be used in the case of dermatological skin diseases, deep moisturising effect, stimulating the production of lipids, and repair processes in the epidermis, These probiotics have a deep moisturising effect, stimulating the production of lipids, and repair processes in the epidermis, the number of unfavourable pathogens is eliminated or reduced, the production of toxic metabolites is reduced, the production of antibodies is increased, the homeostasis of the immune system is restored, and the synthesis of the cytokines is regulated.

Author: Ruth B Cuvas-Limón, Pedro Ferreira-Santos , Mario Cruz , José António Teixeira Ruth Belmares , Clarisse Nobre

effective in the treatment, novel functional beverage , health benefits of probiotic bacteria with the Aloe vera plant, functional beverage containing probiotics, prebiotics, SCFA, and phenolic compounds, Aloe vera; lactic acid bacteria; phenolic compounds; antioxidant activity; organic acids; functional food, specific functions of the human body beyond adequate nutritional effects, biogenic compounds, probiotic microorganisms, non-dairy fermented drinks, alternative for specific consumers, different substrate sources , bioactive molecules , microorganisms , biotechnology , development of differentiated products, innovative functional beverage with antioxidant potential and high-value bioactive compounds based on Aloe vera fermentation by a novel isolated probiotic LAB, food grade, Organic Acids in the Fermented Juice,

Author: Ruth B. Cuvas-Limón, Pedro Ferreira-Santos, Mario Cruz, José António Teixeira, Ruth Belmares, and Clarisse Nobre.

Aloe vera, bioactive compounds, aloe fermented beverages formulation, novel functional beverage development, health benefits of probiotic bacteria with the Aloe vera, Lactococcus lactis, carbohydrates, phenolic compounds, biotransformation , Enterococcus faecium, Lactic acid and short-chain fatty acids (SCFA), antioxidant activity; functional food; lactic acid bacteria; organic acids;

Author: Gibson G.R., Roberfroid M.B.

Bacteria , growth & development, Bacteria metabolism, Bifidobacterium ,growth & development, Colon,drug effects, Colon ,microbiology, Dietary Carbohydrates metabolism, Dietary Carbohydrates , Fermentation, Humans, Lactobacillus , growth & development, Oligosaccharides metabolism, manipulation of the composition of the gut flora, health-promoting properties, microbial food supplements , intestinal microbial balance, composition of colonie microbiota, Intake of prebiotics, modulate the colonie microbiota, synbiotics is colonie foods with interesting nutritional properties , health-enhancing functional food ingredients, host health and nutrition, colonic bacteria produce short-chain fatty acids (SCFA) fromthe metabolism of complex carbohydrates and proteins, manipulation of the composition of the gut flora, increase the health-promoting attributes , beneficial species are the bifidobacteria and lactobacilli, combination of both probiotics andprebiotics as synbiotics, synbiotics be defined as a mixture of probiotics and prebiotics that beneficially affects the host by improving the survival and implantation of live microbial dietary supplements in the gastrointestinal tract, by selectively stimulating the growth and/or by activating the metabolism of one or a limited number of health-promoting bacteria, and thus improving host welfare.

Author: Liyu Luo†c, Ming Zhongd, Tanggui Xied, Yuling Liu

Traditional Herbal Medicine, effective ingredients in the herbal formulations ,botanical extracts mechanisms of action, bioavailability , treatment of disease, function of gut microbiota , active metabolites, gut microbiota balance, regulating the fermentation products of the gut microbes, pharmacodynamic , aloe vera preparations, with therapeutic activity, physiological activity, herbal formulations, composition, gut microbiome is very important for human health , genes encoded by the gut bacteria , gut meta-genome, human tissues and bacteria interact , host genome , absorption of nutrients, neurodevelopment, transmission, fat metabolism, immune responses, portal system, gut epithelial permeability,

Author hakib, Z.; Shahraki, N.; Razavi, B.M.; Hosseinzadeh, H. S

Metabolic syndrome, risk factors, hyperglycemia, dyslipidemia, hypertension, and obesity, type II diabetes mellitus and cardiovascular problems, health concerns , sedentary lifestyle, high levels of subjective stress, and unhealthy diets, health care approaches, aloe barbadensis Miller, aloe gel beneficial properties, dyslipidemia

Author: MohsenMazidiabPeymanRezaiecAndre Pascal Kengned Majid Ghayour Mobarhance Gordon A. Ferns f

Metabolic syndrome, Microbiome Human, gut Diet, Gut microbiota, Obesity, Diabetes, Non-alcoholic fatty liver disease, Probiotic, Prebiotic, Bariatric surgery

Author: by Antonio Tornero-Martínez, Rubén Cruz-Ortiz , María Eugenia Jaramillo-Flores, Perla Osorio-Díaz, Sandra Victoria Ávila-Reyes, Guadalupe Monserrat Alvarado-Jasso and Rosalva Mora-Escobedo.

Soluble or fermentable fibre, prebiotic effects, Bifidobacterium and Lactobacillus strains, colonic fermentation produces short chain fatty acids (SCFAs), fibre , polyphenolic compounds, digestion , colonic fermentation , polysaccharide extract from Aloe vera, colon fermentation, Aloe vera and polysaccharide extract as prebiotics, aloe vera plant matrix, Aloe barbadensis Miller, carbohydrate acemannan , soluble molecules, Soluble or fermentable fibre components, such as mannans, galactans, arabinans, arabinogalactans, and pectic substances, could have prebiotic effects, intestinal microbiota metabolism, Acetate (C2), propionate (C3), and butyrate , digestion of gel and a polysaccharide extract from Aloe vera

Author Samantha R Ellis , Mimi Nguyen , Alexandra R Vaughn, Manisha Notay , Waqas A Burney , Simran Sandhu , Raja K Sivamani

Microorganisms in the skin, relationship between the gut and skin microbiome and various dermatological diseases including acne, psoriasis, rosacea, and atopic dermatitis, microbiome and the role of probiotics, skin is comprised of three major habitats: moist, sebaceous, and dry, Sebaceous skin includes the face, chest, and back, Dry skin sites, such as the arms and legs, Invaginations of the skin as hair follicles, sebaceous glands, and sweat glands, skin microbiome is important in homeostasis, enhance the innate barrier immunity, promote tissue repair, cutaneous immune system, microbial ecosystems, human genome and gut microbiome , fermentation of complex carbohydrates, gut microbiota’s composition or metabolic activity may also alter fatty acid levels , intricate ecological community, metabolic byproducts and host interactions, influence both normal physiology and disease processes, microbial diversity in the gut and on the skin influences health, associations between skin and gut microbiota and dermatologic conditions such as atopic dermatitis, acne, rosacea, and psoriasis, Gut-Skin Communication,

Author: Leah T Stiemsma, Reine E Nakamura, Jennifer G Nguyen, Karin B Michels

fermented foods; lactic acid bacteria; microbiota; probiotics; yogurt, Bacteria / classification , Fermented Foods, Gastrointestinal, Microbiome

Author: Liu J, Zhu H, Li B, Lee C, Alganabi M, Zheng S, Pierro A.

Butyrate is a short-chain fatty acid, intestinal epithelium, intestinal epithelial cells, synthesized from non-absorbed carbohydrate by colonic microbiota, transepithelial fluid transport, intestinal motility, mucosal inflammation, potent regulatory effects on gene expresión, intestinal ecosystem, gastrointestinal functions, The intestinal ecosystem essentially comprises the epithelium, immune cells, enteric neurons, intestinal microflora, and nutrients, extraintestinal diseases, organic acids, microbial fermentation , dietary fiber, colonic lumen, acetate, propionate, acidic fermentation products, luminal pH, colon, Ion absorption, Cell proliferation, Cell differentation, Immune-regulation, Visceral perception and rectal compliance, non-specific intestinal defense mechanisms.

Author: Ahluwalia B, Magnusson MK, Bohn L, Storsrud S, Larsson E, Savolainen O, Ross A, Simren M, Ohman L.

Aloe barbadensis Mill., potential prebiotic effects, fecal microbiota and metabolites, inulin, BS Symptom Severity Score (IBS-SSS), metabolomic profile, Aloe treatment, aloe fermented , gastrointestinal symptoms; irritable bowel syndrome; prebiotic.

Author: M.B. Lousada,T. Lachnit,J. Edelkamp,T. Rouillé,D. Ajdic,Y. Uchida,A. Di Nardo,T.C.G. Bosch,R. Paus

Microbiome to Hair Physiology and Regeneration, microbial colonization, metagenomics, inflammatory milieu, inflammatory cutaneous diseases, immunological interactions, follicular epithelium, hair follicle bacterial, microorganisms and metabolism on host tissue, symbiotic relationship, follicular microbial communities, HF immunology, cycling, and regeneration, sebaceous gland function, microbial commensals

Author S. Basannavar, R. Pothuraju, R.K. Sharm

Aloe vera; Lactobacillus casei; angiotensin-converting enzyme; proteolysis; viability, Aloe vera has a good functional ingredients,

Author:Gullón, B.; Gullón, P.; Tavaria, F.; Alonso, J.L.; Pintado, M.

Aloe, mucus, oligosaccharide, enteric microbe, in vitro experiment , human(primates) , microflora , side chain , fermentation , fatty acid , FISH , hexose , aldose , pentos, Aloe vera, Prebiotics, short chain fatty acid , quantification

Authors: Julian R Marchesi, David H Adams, Francesca Fava, Gerben D A Hermes, Gideon M Hirschfield, Georgina Hold, Mohammed Nabil Quraishi, James Kinross, Hauke Smidt, Kieran M Tuohy, Linda V Thomas, Erwin G Zoetendal, Ailsa Hart.

fermented Autoimmune Diseases – microbiology , Bacteria, Bacteria – metabolism, Carbohydrates, Care and treatment, Colitis, Ulcerative – microbiology, Colorectal cancer , Crohn Disease – microbiology , Diagnosis, Diet , Disease , Dosage and administration, Gastrointestinal Microbiome – physiology , Gene expresión, Inflammation , Inflammatory Bowel Diseases – microbiology , INTESTINAL BACTERIA ,Metabolic disorders ,Metabolites , Microbiota (Symbiotic organisms) , Microorganisms , Non-alcoholic Fatty Liver Disease – microbiology , Obesity – etiology , Polyphenols – metabolism , Prebiotics , Probiotics , Small intestine , Studies,

Author: Meixiu Jiang, Kan Deng, Chunling Jiang, Mingui Fu, Chunlan Guo, Xiaolei Wang, Xin Wang, Fanjing Meng, Shaoguo Yang, Keyu Deng, Tingtao Chen, Hongbo Xin

Aloe fermentation , supernatant, functional beverage, cosmetic ingredients, human intestinal health, delaying senescence, prevent chronic diseases, develop Aloe vera (AV) using probiotics, functional beverage, cosmetic ingredient, human intestinal health, delaying senescence, prevent chronic diseases, probiotics are the hotspot for microbiologist and nutritionists , health awareness , busy lifestyle, probiotics industrial uses in dairy products, fermented foods (sauerkraut, sourdough, sausages, cheeses, wines, olives, and pickled vegetables), environments (cow-dung, silage, and sewage), human mouth, intestinal tract, and stools , development of functional foods and potential oral vaccines, growth of probiotics, glucose and skimmed milk were added in the Aloe Vera extract, lactic acid and acetic acid

Author: McRorie, J.W., Jr.; Nicola, M.; McKeown

physical effects of fiber in the gut, fiber supplements, benefits of cholesterol lowering, improved glycemic control, and normalizing stool , constipation, diarrhea, gel-forming fibers , fructooligosaccharides, gut mucosa, mucous secretion, beneficial health effect, straight-chain or linear polymers

Author: Katarzyna Polak?Witka, Lidia Rudnicka,Ulrike Blume?Peytavi, Annika Vogt

scalp hair follicle, alopecia, bacteria, immune system, inflammation, nanoparticles different skin regions depending on pH, temperature, moisture and sebum content, lifestyle habits or used cosmetics, unique lipid?rich hydrophobic niche, hair diseases, skin flora, anagen bulbs, bacteria colonize normal scalp structures of HF, disturbance of the HF immune system, topical application of drugs

Author L.-C. Lew and M.-T. Liong

probiotics may exert other health-promoting effects beyond gut well-being, gut–brain axis correlations, healing of burn and scars, skin-rejuvenating properties and improving skin innate immunity, immune responses on the skin and improve skin barrier functions, probiotic strains with potential dermal enhancing properties for topical applications, probiotic are live microorganisms which when administered in adequate amount confer a health benefit to the host, Cell-free cultures of lactic acid bacteria with probiotic , use of probiotic in nonviable forms , probiotic exert dermal benefits , adherence capacity to the cellular substrate , probiotic dermal formulations,

Authors: Ravinder Nagpal et al.

Aloe, Drug Combinations, Drug Compounding, Hydrogen-Ion Concentration, Lactobacillus / drug effects, Lactobacillus / physiology, Microbial Sensitivity Tests, Phytotherapy, Plant Components, Aerial, Plant Preparations / pharmacology, Probiotics

Author Peng L, Li ZR, Green RS, Holzman IR, Lin J.

Butyrate, SCFA, intestinal barrier, molecular mechanisms, transepithelial electrical resistance (TEER), inulin permeability , specific AMPK inhibitor, epithelial tight junctions, activation of the AMP-activated protein kinase , butyrate-induced activation, the intracellular energy sensor , intriguing link between SCFA and the intracellular energy sensor

Author: Laparra, J.M.; Sanz, Y.

metabolic and immune functions, nutritional and health status of the host, nutritional and health status of the host, development of the functional food concept and nutraceuticals, Prebiotics, polyunsaturated fatty acids (PUFAs) , phytochemicals, dietary bioactive compounds, biological roles, immunity and metabolism, metabolic products, food compounds acquired orally, nutritional intervention, gut mirobiota; functional foods; nutraceuticals; prebiotics; polyunsaturated fatty acids; phytochemicals, nutritional and health status of the host, nutrient acquisition strategies, Nutraceuticals are extracts containing the biologically active food components supplied in other than a food form, Dietary components with biological effects are susceptible to be metabolized by intestinal bacteria during the gastrointestinal passage, prior being absorbed, functional food components, biological activity of food compounds, epithelium , gut-associated lymphoid tissue, immunomodulatory roles, probiotic strains, Helicobacter pylori infection, complex polysaccharides are the primary energy source for the colonic microbiota.

Author: A Yagi, A Kabbash, LA Al-Madoboly

Aloe vera, Aloe vera polysaccharides, in vitro fermentation, SCFAs, capacity, aloe vera gel could potentially be used as a source of natural elastase and ?-amylase inhibitory activities and anti-oxidant activity in pharmaceutical, cosmetic and food industries, Calorie restriction (CR) without malnutrition, suppressing oxidative stress-induced chronic inflammation that underlies many chronic diseases, aging is caused by increased free radical damage , weakened defense system, oxidative stress, age-related gut dysfunction, lactic acid bacteria as the likely candidate responsible for the anti-obesity effect, innovative approach on the symbiotic effect by blending Lactobacillus fermentum into aloe vera juice to yield lactic acid, acetic acid, and propionic acid in the fermentation extract, Butyrate boost metabolism, overweight , sleep disorders

Author: Wong, J.M.W.; Souza, R.; Kendall, C.W.C.; Emam, A.; Jenkins, D.J.A.

in short chain fatty acids (SCFAs) with the emergence of prebiotics and probiotics aimed at improving colonic and systemic health, substrates for fermentation, SCFAs, primarily acetate, propionate, and butyrate, as end products, substrate source, SCFAs are readily absorbed, Butyrate is the major energy source for colonocytes, Propionate is largely taken up by the liver. Acetate enters the peripheral circulation to be metabolized by peripheral tissues, acetate is the principal SCFA in the colon, and after absorption it has been shown to increase cholesterol synthesis, propionate, a gluconeogenerator, has been shown to inhibit cholesterol synthesis, propionate ratio may reduce serum lipids and possibly cardiovascular disease risk, Butyrate has been studied for its role in nourishing the colonic mucosa and in the prevention of cancer of the colon, promoting cell differentiation, Butyrate in the treatment of colitis, functional foods, conversion of bioactive substances such as phytoestrogens to promote or retard their absorption from the colon, irritable bowel syndrome, inflammatory bowel disease, cardiovascular disease, and cancer, exerting prebiotic-like effects

Author: Wang RX, Lee JS, Campbell EL, Colgan SP.

Intestinal epithelial barrier dysfunction, dysbiosis, SCFA butyrate, epithelial wound-healing responses, intestinal tight junction protein, homeostatic intestinal mucosal function, selective regulation of SYNPO, Disruption , inflammatory bowel diseases (IBDs), mucosal inflammation , epithelial barrier function, wound healing, Microbial supply of butyrate, fermentation-derived short-chain fatty acid (SCFA), gut homeostasis, microbiota aids digestion, energy source for colonocytes, derived butyrate absorbed, propionate and acetate enter hepatic circulation

Author: Clifton, P.M.

small intestinal digestion, large bowel, Human colonic bacteria ferment, dietary fiber, protective against colorectal cancer via butyrate, prebiotic, microflora can metabolize proteins, products of fermentation, metabolic end products, acetate, propionate, butyrate , lactate , succinate, chain SCFA, amino acids, formula-fed infants, Carbohydrates entering the large bowel , luminal anions in humans, Fermentable carbohydrates, beneficial lactic acid bacteria, probiotics , improve host health

Author Seong-Hun Lee, Chang-Ho Eun, Yong-Seong Kwon , Jin-Hong Baek , In-Jung Kim

Functional Ingredients, Fermented Extracts of Aloe vera, adipocyte differentiation inhibition; aloe byproduct; antioxidant; fermentation; hyaluronic acid; tyrosinase inhibition, aloe beverage manufacturing process, aloe processing byproducts (BF and PF), tyrosinase inhibition, radical scavenging, superoxide dismutase, biological potential for applications in the manufacturing of cosmetics, pharmaceuticals, and beverages, butyrate fermented by endophytic microbiota in Aloe vera gel, e aloe beverage manufacturing process, fermentation products of processing byproducts, functional biological materials for cosmetic, pharmaceutical, and beverage manufacturing,

Author Teerapong Rattananukrom , Aisawan Petchlorlian ,Iyarit Thaipisuttikul and Mongkhon Sompornrattanaphan

The skin has a multifactorial aging process, oxidative damage, skin’s antioxidant system tends to weaken with age, alteration of the intestinal bacteria, microbial dysbiosis, skin interactome , genome-microbiome-exposome, delay skin aging , human microbiomes affect skin aging , Probiotics-based products, add-on treatment of many dermatologic conditions, skin anti-aging purposes , therapeutic options, , dermatological and cosmetologically treatments, aging process, Biologic aging is a process occurring at the cellular and molecular level, deterioration in the function and structure of all of the organ systems,  live a longer and healthier life,  live a longer and healthier life, ingestion of an unbalanced diet, Molecular mechanism of aging, cellular aging, Cellular senescence, skin has a multifactorial aging process,  chronologic skin aging, genetic, hormones, and cellular metabolic changes, metabolites from the gut and skin microbiome, soft tissue changes including decreased collagen production, lower amounts of lipids, epidermal thinning, and the loss of subcutaneous fat, aged skin appears dry and pale with fine wrinkles and increased laxity, Facial aging , soft tissue changes, facial bone resorption, and recession, ultraviolet radiation, skin manifests deep wrinkles, laxity, coarseness, increased fragility, and multiple telangiectasias, photodamaged skin may exhibit depigmentation such as darkening and mottled pigmentation,  solar elastosis, reduced number of fibroblasts, and decreased amount of extracellular matrix ,weak skin’s antioxidant system , collagen degradation, oxidative stress , Oxidative insult, skin disease or systemic disease , imbalance of commensals and pathogens, microorganisms are variably present at the surface compared with deeper skin layers, capture of skin microbiota , distribution of microorganisms in the skin, microbial diversity and a greater inter-individual variation in microbiota composition in old people, longevity is positively associated with an abundance of short-chain fatty acid (SCFA) producers,  signature for longevity, good immunological and metabolic health-related bacteria, decreased levels of Bifidobacterium, Bacteroides, and Enterobacteriaceae, and increase Clostridium spp. Levels, aging-associated differences in gut microbiota , according to age-related changes in microbiome diversity,  loss of diversity in the core microbiota groups.

Author R. Sfriso,M. Egert,M. Gempeler,R. Voegeli,R. Campiche

human skin microbiome, dermatological and cosmetic fields, skin microbiota, collection of vital microorganisms living on our skin, maintain its delicate balance is an essential step to gain insight into the mechanisms responsible for healthy skin and its appearance, development of approaches which preserve or restore the natural, individual balance of the microbiota represents a novel target not only for dermatologists but also for skincare applications, skincare segment to help restoring and balancing the structure and functionality of the skin microbiota, hair follicles and sweat ducts, main skin function is to maintain homeostasis by preventing water and extracellular fluid loss (permeability barrier), by keeping a constant body temperature, healthy-looking human skin also harbours resident or transient viruses, skin surface depends on physiological characteristics (pH, temperature, sebum content and moisture (linked to the presence of sweat and sebaceous glands distributed across the skin)), topography (rough or smooth surface of the corneocytes) as well as on exogenous environmental factors – such as UV exposure, temperature and humidity – and it is reflected in a differential microbial colonization, skin conductance and transepidermal water loss (TEWL), differential microbial colonization , stratum corneum, the skin-resident microbiota guarantees protection and a biological barrier, skin microbiota composition, Damaged skin barrier with dysbiosis, skin pH, dendritic epidermal T cells.

Author Nishu Goyal & Frankine Jerold

conventional fossil-based ingredients , cosmetics with natural effective ingredients, Bioactive · Adjuvants · Organoclay · Formulations · Microbiome, bioactive ingredient, product development, and formulation processes, Biocosmetics are cosmetic products made from 100% natural ingredients , skin-care cosmetic formulations, circular economy, customer demand for green cosmetics and addressing environmental concerns, sustainable, natural, and greener cosmetics, nature, key ingredients in a cosmetic formulation, Active ingredients, renewable bio-based alternatives, sourcing/extracting bio-based ingredients, nanoformulations, chemical composition of the ingredients, chemistry of a cosmetic formulation, impact of the formulation on our health, aloe Organic substances, biological cosmetics, alternative substances of natural origin, vegan raw materials, fermentation of plant-based, skincare products to target skin concerns

Author: Janny Melissa Mendoza Mencia,

aloe fermented yogurt, production of fermented milk drinks from lactic acid bacteria, nutritional value, great sensory attributes, functional beverages, viscosity, antioxidant capacity, yogurt formulations with aloe ,probiotic and non-probiotic yogurt, Nutritional value of yogurt, aloe vera juice, high content of bioactive compounds, aloe vera juice pH, Luminosity, good bacteria, gastrointestinal system, yogurt starter cultures, nutritional value, bioactive compounds, supplement for functional foods, functional and nutritive foods , functional component in aloe vera is the polysaccharide acemannan, prebiotics, functional ingredient, stimulate the favorable growth or metabolism of beneficial bacteria , develop a functional plain stirred yogurt enhanced with inulin and aloe vera, milk fermentation converting lactose to lactic acid, probiotic bacteria

Author Willem M de Vos , Herbert Tilg , Matthias Van Hul ,Patrice D Can

regulator of host health, body sites are colonized by microbes suggesting different types of crosstalk with our organs, microorganisms, development of molecular tools and techniques , gut microbiota deviations, immunity, energy, lipid and glucose metabolism , gut bacteria ,molecular actors , specific receptors, novel therapies, oral and saliva microbiomes, metabolic syndrome or autoimmune disease, response to glucose, intestinal and extraintestinal disorders, metabolite disturbances, inflammatory disorders of the intestine, functional disorder of the GI, oral microbiome, Western world, receptors on host cells, molecular mechanisms, digestion and absorption of simple carbohydrates, colon, SCFAs molecules , modulation of energy homeostasis, glucose/lipid metabolism, inflammation and even immunity

Author: Nicola Procházková,Gwen Falony, Lars Ove Dragsted,Tine Rask Licht4,Jeroen

gut microbiota, composition, activity, human health, diversity and metabolism, gut motility, gut transit time, gut microbiome variations in health and disease, gut transit time including sex, ageing, stress, body mass index, colonic anatomy, gut hormones and diet, Dietary patterns, dietary factors, dietary fibres, mechanical stimulation of the intestinal epithelium, Fermentable fibres such as inulin seem to alleviate constipation and improve physical discomfort, gut microbial metabolism

Authors: Sarkar, Amar , Lehto Soili M , Harty Siobhán , Dinan, Timothy G, Cryan, John F , Burnet Philip W.J

mental health benefits through interactions with commensal gut bacteria, prebiotics, which enhance the growth of beneficial gut bacteria, psychobiotic effects, psychobiotics are beneficial bacteria (probiotics) or support for such bacteria (prebiotics) that influence bacteria–brain relationships, Psychobiotics exert anxiolytic and antidepressant effects characterized by changes in emotional, cognitive, systemic, and neural indices, psychobiotics exert effects include the enteric nervous system and the immune system, manipulate commensal gut bacteria with psychobiotics, Psychobiotics affect psychophysiological markers, Lactobacillus rhamnosus R0011 and Lactobacillus helveticus R0052, mitigated colonic dysfunction

Author: Minh Q. Ngo, Pharm.D., Nancy N. Nguyen, Pharm.D., Sachin A. Shah, Pharm.D.

Aloe vera extract, alternative medicine, diabetes mellitus, dose response drug , efficacy dyslipidemia, human, hypercholesterolemia , hiperlipidemia, impaired glucose tolerance lipid metabolism, non-insulin dependent diabetes mellitus , Aloe, blood glucosa, blood leve loral drug administration phytotherapy plant leaf, Administration Oral,Aloe, Blood Glucose, Cholesterol , Complementary Therapies, Diabetes mellitus,Humans, Hypoglycemic Agents, Hypolipidemic Agents , Phytotherapy Leaves

Author Anthony J Bilotta, Yingzi Cong

regulation of host homeostasis, composition and function of the microbiota, saturated fats, bacterial metabolites of dietary fiber, short chain fatty acids (SCFAs), healthy microbiome, epithelial and immune cell functions in the intestines, therapeutic application, host defense, Ulcerative colitis, Crohn’s disease, acetate, propionate, and butyrate ,role for gut microbiota metabolites in modulating intestinal homeostasis and immunity, with dietary fibers and their bacterial fermentation products, short chain fatty acids (SCFAs), playing an essential part, bacterial fermentation of dietary fibers, colonic cells, SCFA absorption occurs by three mechanisms: passive diffusion, electroneutral, or electrogenic uptake, SCFAs are able to stimulate mucus production, SCFAs stimulate antimicrobial peptides , SCFAs regulate the daily turnover of the epithelial lining and regulate stem cell proliferation, SCFA regulation of tight junctions, SCFAs and immune regulation, SCFA regulation of neutrophils, SCFA regulation of T lymphocytes, SCFA regulation of macrophages, SCFA regulation of dendritic cells,

Author: Akira Yagi, Byung P. Yu

Carbohydrate-based immune adjuvants, Aloe vera; Acemannan; Immunomodulator; Biological vehicle; Adjuvant; Drug delivery system; Plant sterols; Gut microbiota modulator, plant sterols and polyphenols, aloe’s immune efficacy, molecules in Aloe vera, role of biological vehicle in drug delivery system, enhance immunogenicity, provide antigen-dose sparing,accelerate the immune response, Biogenic , trans-epithelial electrical resistance (TEER), open tight junctions, immune adjuvant, complex gut microbial community.

Author: Akira Yagi, Byung Pal Yu

Aloe vera gel; Butyrate; Obesity; Calorie restriction, metabolites of Aloe vera polysaccharide, insulin sensitivity, metabolites modify microbiota status, Intestinal epithelial cells take up SCFAs , biological aging process and the age-related disease process, Aloe vera supplement

Author Akira Yagi, PhD; Byung Pal Yu, PhD

aloe vera gel ingestión, actions of fermented butyrate, aloe vera gel on healthy aging, skin photo-aging, and the viability and lifespan, skin aging, consuming aloe vera gel improves skin elasticity, boosts collagen production, and significantly reduces wrinkles, Disturbance in the gut microbiota, nutraceuticals including probiotics, prebiotics and aloe vera are known to enhance gut microbial homeostasis, aloe vera gel leads to increased fermentation and promotes the bacterial growth , probiotic effect of aloe vera,

Authors: Kenji Koizumi, MD, PhD, Megumi Hasegawa, Akira Mukaitani, Akira Yagi PhD

fermented aloe butyric and propionic acid, renal protective effect of aloe plant extract, toxins, Endophytically fermented aloe plants extract, Gastroenterology and Hepatology Research, complex and dynamic consortium of bacteria, gut microbiome plays important roles, microbiome is disturbed due to the proliferation of dysbiotic bacteria, gut bacteria generates excess amounts of potentially toxic compounds such as ammonia, amines, thiols, phenols, and indoles, but the generation of short chain fatty acids is reduced, modification of gut microbiota, harmful metabolites, beneficial metabolites such as short chain fatty acid (SCFA), Butyrate is the primary source of energy for colonocytes and is thus associated with maintenance of epithelium, colonic short-chain fatty acids (butyric, propionic and succinic acid), Microbiota-derived SCFAs, leaky gut , transporters for SCFA, transporters for SCFA, colon walls, systemic inflammation, fermentable high fiber diet, health-promoting benefits, microbiota-derived metabolites can regulate the incretin axis and mitigate inflammation via expansion of regulatory T cells, reducing the number of pathobionts , enhances intestinal motility, Long-term dietary intake of non-caloric water-soluble fiber, prebiotic activity of aloe vera juice , aloe vera gel influences the structural and activity of microorganisms in human gut

Author: Yagi Akira Yagi1, PhD; Megumi Hasegawa2; Miiko Mikami3; Suzuka Ataka4, MD, PhD

Aloe vera; Butyrate fermented; Hyaluronan; Irritable bowel syndrome; IBS subgroups, short-chain fatty acids , diagnostic biomarker for irritable bowel syndrome , mucus-eroding microbiota, intestinal barrier , Metabolic syndrome (MetS)